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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PDE6 alpha/PDE6A Antibody Picoband®

SKU : BHA21002778

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Mfr.No.	A07800-1, A07800-1-10ug, A07800-1-Biotin, A07800-1-Cy3, A07800-1-Dylight488, A07800-1-Dylight550, A07800-1-Dylight594, A07800-1-FITC, A07800-1-HRP, A07800-1-APC, A07800-1-PE, A07800-1-iFluor647, A07800-1-carrier-free
Alternative Names	SRY-box 15
Background	This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PDE6 alpha/PDE6A Antibody Picoband® catalog # A07800-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to the 5'-AACAAT-3' sequence.
Host	Rabbit
Immunogen Region	E.coli-derived human PDE6 alpha/PDE6A recombinant protein (Position: K11-R237).
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Protein SOX-15; Protein SOX-12; Protein SOX-20; SOX15; SOX12; SOX20; SOX26; SOX27
Tissue Specificity	Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P16499
Gene Id	5145
Gene Name	PDE6A
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25ug/ml,Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 4ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Corton, M., Blanco, M. J., Torres, M., Sanchez-Salorio, M., Carracedo, A., Brion, M. Identification of a novel mutation in the human PDE6A gene in autosomal recessive retinitis pigmentosa: homology with the nmf28/nmf28 mice model. (Letter) Clin. Genet. 78: 495-498, 2010.<br /><br />2. Khan, S. Y., Ali, S., Naeem, M. A., Khan, S. N., Husnain, T., Butt, N. H., Qazi, Z. A., Akram, J., Riazuddin, S., Ayyagari, R., Hejtmancik, J. F., Riazuddin, S. A. Splice-site mutations identified in PDE6A responsible for retinitis pigmentosa in consanguineous Pakistani families. Molec. Vision 21: 871-882, 2015.<br /><br />3. Tuntivanich, N., Pittler, S. J., Fischer, A. J., Omar, G., Kiupel, M., Weber, A., Yao, S., Steibel, J. P., Khan, N. W., Petersen-Jones, S. M. Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation. Invest. Ophthal. Vis. Sci. 50: 801-813, 2009.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002778-1	A07800-1	-	100 ug	$370		Add to Cart
BHA21002778-2	A07800-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002778-3	A07800-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002778-4	A07800-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002778-5	A07800-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002778-6	A07800-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002778-7	A07800-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002778-8	A07800-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002778-9	A07800-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002778-10	A07800-1-APC	APC	100 ug	$670		Add to Cart
BHA21002778-11	A07800-1-PE	PE	100 ug	$670		Add to Cart
BHA21002778-12	A07800-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002778-13	A07800-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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