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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PDCD4 Antibody Picoband®

SKU : BHA21005299

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Mfr.No.	A01105-4, A01105-4-10ug, A01105-4-Biotin, A01105-4-Cy3, A01105-4-Dylight488, A01105-4-Dylight550, A01105-4-Dylight594, A01105-4-FITC, A01105-4-HRP, A01105-4-APC, A01105-4-PE, A01105-4-iFluor647, A01105-4-carrier-free
Alternative Names	Programmed cell death protein 4
Background	Programmed cell death protein 4 (PDCD4) is a protein that in humans is encoded by the PDCD4 gene. It is mapped to 10q25.2. This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. It also encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PDCD4 Antibody Picoband® catalog # A01105-4. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of
Host	Rabbit
Immunogen Region	E.coli-derived human PDCD4 recombinant protein (Position: D160-L363).
Isotype	Rabbit IgG
Molecular Weight	64 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Programmed cell death protein 4;Neoplastic transformation inhibitor protein;Nuclear antigen H731-like;Protein 197/15a;PDCD4;H731;
Tissue Specificity	Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q53EL6
Gene Id	27250
Gene Name	PDCD4
Subcellular Location	Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Azzoni, L; Zatsepina, O; Abebe, B; Bennett, IM; Kanakaraj, P; Perussia, B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Joual of immunology 161 (7): 3493500. <br /><br />2. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 61721.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005299-1	A01105-4	-	100 ug	$370		Add to Cart
BHA21005299-2	A01105-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21005299-3	A01105-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005299-4	A01105-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005299-5	A01105-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005299-6	A01105-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005299-7	A01105-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005299-8	A01105-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21005299-9	A01105-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21005299-10	A01105-4-APC	APC	100 ug	$670		Add to Cart
BHA21005299-11	A01105-4-PE	PE	100 ug	$670		Add to Cart
BHA21005299-12	A01105-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005299-13	A01105-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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