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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PBP/PEBP1 Antibody Picoband®

SKU : BHA21007000

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Mfr.No.	PA1713, PA1713-10ug, PA1713-Biotin, PA1713-Cy3, PA1713-Dylight488, PA1713-Dylight550, PA1713-Dylight594, PA1713-FITC, PA1713-HRP, PA1713-APC, PA1713-PE, PA1713-iFluor647, PA1713-carrier-free
Alternative Names	Phosphatidylethanolamine-binding protein 1
Background	PEBP1 (Phosphatidylethanolamine-binding protein 1), also called PBP, RKIP, inhibits the phosphorylation and activation of MEK by RAF1. PEBP1 is identical to the phosphatidylethanolamine-binding protein (PBP) with a relative molecular mass of 23 kD. The PEBP1 gene is mapped on 12q24.23. PEBP1 coimmunoprecipitates with RAF1 and MEK from cell lysates and colocalizes with RAF1 when examined by confocal microscopy. PEBP1 overexpression interferes with the activation of MEK and ERK, induction of AP1-dependent reporter genes, and transformation elicited by an oncogenically activated RAF1 kinase. PEBP1 expression was rapidly upregulated during induction of chemotherapy-triggered apoptosis in human prostate and breast cancer cell lines, and maximal RKIP expression correlated perfectly with the onset of apoptosis by Chatterjee et al (2004). RKIP depletion decreased the mitotic index, the number of metaphase cells, traversal times from nuclear envelope breakdown to anaphase, and an override of mitotic checkpoints induced by spindle poisons.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PBP/PEBP1 Antibody catalog # PA1713. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elas
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of mouse PBP, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	21 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Phosphatidylethanolamine-binding protein 1;PEBP-1;HCNPpp;Hippocampal cholinergic neurostimulating peptide;HCNP;Pebp1;Pbp, Pebp;
Tissue Specificity	HCNP is expressed in brain. Increased expression in aged senescence-accelerated mice.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P70296
Gene Name	PEBP1
Sequence	Belongs to the MCM family.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Chatterjee, D., Bai, Y., Wang, Z., Beach, S., Mott, S., Roy, R., Braastad, C., Sun, Y., Mukhopadhyay, A., Aggarwal, B. B., Daowski, J., Pantazis, P., Wyche, J., Fu, Z., Kitagwa, Y., Keller, E. T., Sedivy, J. M., Yeung, K. C. RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J. Biol. Chem. 279: 17515-17523, 2004.<br /><br />2. Hengst, U., Albrecht, H., Hess, D., Monard, D. The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors. J. Biol. Chem. 276: 535-540, 2001. <br /><br />3. Yeung, K., Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, C., Fee, F., Katsanakis, K. D., Rose, D. W., Mischak, H., Sedivy, J. M., Kolch, W. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401: 173-177, 1999. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007000-1	PA1713	-	100 ug	$370		Add to Cart
BHA21007000-2	PA1713-10ug	Sample	10 ug	$99		Add to Cart
BHA21007000-3	PA1713-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007000-4	PA1713-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007000-5	PA1713-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007000-6	PA1713-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007000-7	PA1713-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007000-8	PA1713-FITC	FITC	100 ug	$570		Add to Cart
BHA21007000-9	PA1713-HRP	HRP	100 ug	$570		Add to Cart
BHA21007000-10	PA1713-APC	APC	100 ug	$670		Add to Cart
BHA21007000-11	PA1713-PE	PE	100 ug	$670		Add to Cart
BHA21007000-12	PA1713-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007000-13	PA1713-carrier-free	carrier-free	100 ug	$370		Add to Cart

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