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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PAK6 Antibody Picoband®

SKU : BHA21007014

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Mfr.No.	PA1729, PA1729-10ug, PA1729-Biotin, PA1729-Cy3, PA1729-Dylight488, PA1729-Dylight550, PA1729-Dylight594, PA1729-FITC, PA1729-HRP, PA1729-APC, PA1729-PE, PA1729-iFluor647, PA1729-carrier-free
Alternative Names	Serine/threonine-protein kinase PAK 6
Background	Serine/threonine-protein kinase PAK 6 (p21 Protein-activated Kinase 6) is an enzyme that in humans is encoded by the PAK6 gene. The PAK6 gene is mapped to chromosome 15q15. based on an alignment of the PAK6 sequence with the genomic sequence. This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PAK6 Antibody catalog # PA1729. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibit
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human PAK6, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Serine/threonine-protein kinase PAK 6;2.7.11.1;PAK-5;p21-activated kinase 6;PAK-6;PAK6;PAK5;
Tissue Specificity	Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9NQU5
Gene Name	PAK6
Sequence	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Subcellular Location	Cytoplasm. Nucleus. Cotranslocates into nucleus with AR in response to androgen induction.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat, Human, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Gross, M. B. Personal Communication. Baltimore, Md. 5/10/2011.<br /><br />2. Yang, F., Li, X., Sharma, M., Zaegar, M., Lim, B., Sun, Z. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J. Biol. Chem. 276: 15345-15353, 2001. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007014-1	PA1729	-	100 ug	$370		Add to Cart
BHA21007014-2	PA1729-10ug	Sample	10 ug	$99		Add to Cart
BHA21007014-3	PA1729-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007014-4	PA1729-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007014-5	PA1729-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007014-6	PA1729-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007014-7	PA1729-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007014-8	PA1729-FITC	FITC	100 ug	$570		Add to Cart
BHA21007014-9	PA1729-HRP	HRP	100 ug	$570		Add to Cart
BHA21007014-10	PA1729-APC	APC	100 ug	$670		Add to Cart
BHA21007014-11	PA1729-PE	PE	100 ug	$670		Add to Cart
BHA21007014-12	PA1729-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007014-13	PA1729-carrier-free	carrier-free	100 ug	$370		Add to Cart

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