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Home / Primary Antibodies / Polyclonal Antibodies

Anti-p95 NBS1/NBN Antibody Picoband®

SKU : BHA21000511

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Mfr.No.	PB9615, PB9615-10ug, PB9615-Biotin, PB9615-Cy3, PB9615-Dylight488, PB9615-Dylight550, PB9615-Dylight594, PB9615-FITC, PB9615-HRP, PB9615-APC, PB9615-PE, PB9615-iFluor647, PB9615-carrier-free
Alternative Names	Nibrin
Background	p95 NBS1, also known as NBN or Nibrin, is a protein which in humans is encoded by the NBN gene. Nibrin is a protein associated with the repair of double strand breaks (DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50 (N/M/R, more commonly referred to asMRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-p95 NBS1/NBN Antibody Picoband® catalog # PB9615. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of t
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human p95 NBS1, different from the related mouse sequence by three amino acids, and from the related rat sequence by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	95 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nibrin;Cell cycle regulatory protein p95;Nijmegen breakage syndrome protein 1;NBN;NBS, NBS1, P95;
Tissue Specificity	Ubiquitous. Expressed at high levels in testis.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O60934
Gene Id	4683
Gene Name	NBN
Sequence	Contains 1 BRCT domain.
Subcellular Location	Nucleus . Nucleus, PML body . Chromosome, telomere . Localizes to discrete nuclear foci after treatment with genotoxic agents. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, By Heat Immunocytochemistry, 0.5-1ug/ml Immunocytochemistry/Immunofluorescence, 5 ug/ml

Reference	1. "Atlas of Genetics and Cytogenetics in Oncology and Haematology - NBS1". 2. Caey JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, Hays L, Morgan WF, Petrini JH (May 1998). "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response". Cell 93 (3): 47786. 3. Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, Seemanová E, Cooper PR, Nowak NJ, Stumm M, Weemaes CM, Gatti RA, Wilson RK, Digweed M, Rosenthal A, Sperling K, Concannon P, Reis A (May 1998). "Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome". Cell 93 (3): 46776.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000511-1	PB9615	100 ug	-	$370		Add to Cart
BHA21000511-2	PB9615-10ug	10 ug	Sample	$99		Add to Cart
BHA21000511-3	PB9615-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000511-4	PB9615-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000511-5	PB9615-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000511-6	PB9615-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000511-7	PB9615-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000511-8	PB9615-FITC	100 ug	FITC	$570		Add to Cart
BHA21000511-9	PB9615-HRP	100 ug	HRP	$570		Add to Cart
BHA21000511-10	PB9615-APC	100 ug	APC	$670		Add to Cart
BHA21000511-11	PB9615-PE	100 ug	PE	$670		Add to Cart
BHA21000511-12	PB9615-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000511-13	PB9615-carrier-free	100 ug	carrier-free	$370		Add to Cart

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