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Home / Primary Antibodies / Polyclonal Antibodies

Anti-p27 KIP 1/CDKN1B Antibody Picoband®

SKU : BHA21007525

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Mfr.No.	PB9070, PB9070-10ug, PB9070-Biotin, PB9070-Cy3, PB9070-Dylight488, PB9070-Dylight550, PB9070-Dylight594, PB9070-FITC, PB9070-HRP, PB9070-APC, PB9070-PE, PB9070-iFluor647, PB9070-carrier-free
Alternative Names	Cyclin-dependent kinase inhibitor 1B
Background	Cyclin-dependent kinase inhibitor 1B (p27KIP1), also known as KIP1 or P27, is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kipfamily of cyclin dependent kinase (Cdk) inhibitor proteins. It is mapped to 12p13.1. p27KIP1 can inhibit both CDK activation and the kinase activity of assembled and activated cyclin-CDK. The function of p27KIP1 is associated with an aggressive phenotype in human breast cancer. Downregulation of p27KIP1 by CK2-alpha-prime is necessary for development of agonist- and stress-induced cardiac hypertrophy.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-p27 KIP 1/CDKN1B Antibody Picoband® catalog # PB9070. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 co
Host	Rabbit
Immunogen Region	E.coli-derived human P27 KIP 1 recombinant protein (Position: S10-T198). Human P27 KIP 1 shares 87% amino acid (aa) sequence identity with mouse P27 KIP 1.
Isotype	Rabbit IgG
Molecular Weight	27 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclin-dependent kinase inhibitor 1B;Cyclin-dependent kinase inhibitor p27;p27Kip1;CDKN1B;KIP1;
Tissue Specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P46527
Gene Id	1027
Gene Name	CDKN1B
Sequence	Belongs to the CDI family.
Subcellular Location	Nucleus. Cytoplasm. Endosome . Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunocytochemistry/Immunofluorescence, 5ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Polyak, K., Lee, M.-H., Erdjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., Massague, J. Cloning of p27(Kip1), a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66, 1994. 2. Hauck, L., Harms, C., An, J., Rohne, J., Gertz, K., Dietz, R., Endres, M., von Harsdorf, R.Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart. Nature Med. 14: 315-324, 2008. Note: Erratum: Nature Med. 14: 585 only, 2008.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007525-1	PB9070	-	100 ug	$370		Add to Cart
BHA21007525-2	PB9070-10ug	Sample	10 ug	$99		Add to Cart
BHA21007525-3	PB9070-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007525-4	PB9070-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007525-5	PB9070-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007525-6	PB9070-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007525-7	PB9070-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007525-8	PB9070-FITC	FITC	100 ug	$570		Add to Cart
BHA21007525-9	PB9070-HRP	HRP	100 ug	$570		Add to Cart
BHA21007525-10	PB9070-APC	APC	100 ug	$670		Add to Cart
BHA21007525-11	PB9070-PE	PE	100 ug	$670		Add to Cart
BHA21007525-12	PB9070-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007525-13	PB9070-carrier-free	carrier-free	100 ug	$370		Add to Cart

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