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Home / Primary Antibodies / Polyclonal Antibodies

Anti-p107/RBL1 Antibody Picoband®

SKU : BHA21007147

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Mfr.No.	PA1894, PA1894-10ug, PA1894-Biotin, PA1894-Cy3, PA1894-Dylight488, PA1894-Dylight550, PA1894-Dylight594, PA1894-FITC, PA1894-HRP, PA1894-APC, PA1894-PE, PA1894-iFluor647, PA1894-carrier-free
Alternative Names	Retinoblastoma-like protein 1
Background	RBL1 (Retinoblastoma-like 1), also known as Cullular Proteins p107, CP107 and 107, is a protein that in humans is encoded by the RBL1 gene. Ewen et al. (1991)used a partial cDNA for human p107 to map the gene to 20q11. by fluorescence in situ hybridization. Huppi et al. (1996)found that the mouse Rbl1 gene maps to the distal end of chromosome 2, as does also the E2f1 gene. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is though that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-p107/RBL1 Antibody catalog # PA1894. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key regulator of entry into cell division. ly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyl
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human p107, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Retinoblastoma-like protein 1;107 kDa retinoblastoma-associated protein;p107;pRb1;RBL1;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P28749
Gene Name	RBL1
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Ewen, M. E., Xing, Y., Lawrence, J. B., Livingston, D. M.Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.Cell 66: 1155-1164, 1991.<br /><br />2. Huppi, K., Siwarski, D., Mock, B. A., Dosik, J., Hamel, P. A.Molecular cloning, chromosomal mapping, and expression of the mouse p107 gene.Mammalian Genome 7: 353-355, 1996.<br /><br />3. Kim, K. K., Soonpaa, M. H., Wang, H., Field, L. J.Developmental expression of p107 mRNA and evidence for alteative splicing of the p107 (RBL1) gene product.Genomics 28: 520-529, 1995.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007147-1	PA1894	-	100 ug	$370		Add to Cart
BHA21007147-2	PA1894-10ug	Sample	10 ug	$99		Add to Cart
BHA21007147-3	PA1894-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007147-4	PA1894-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007147-5	PA1894-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007147-6	PA1894-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007147-7	PA1894-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007147-8	PA1894-FITC	FITC	100 ug	$570		Add to Cart
BHA21007147-9	PA1894-HRP	HRP	100 ug	$570		Add to Cart
BHA21007147-10	PA1894-APC	APC	100 ug	$670		Add to Cart
BHA21007147-11	PA1894-PE	PE	100 ug	$670		Add to Cart
BHA21007147-12	PA1894-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007147-13	PA1894-carrier-free	carrier-free	100 ug	$370		Add to Cart

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