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Home / Primary Antibodies / Polyclonal Antibodies

Anti-OS9 Antibody Picoband®

SKU : BHA21003716

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Mfr.No.	A04158-1, A04158-1-10ug, A04158-1-Biotin, A04158-1-Cy3, A04158-1-Dylight488, A04158-1-Dylight550, A04158-1-Dylight594, A04158-1-FITC, A04158-1-HRP, A04158-1-APC, A04158-1-PE, A04158-1-iFluor647, A04158-1-carrier-free
Alternative Names	eukaryotic translation termination factor 1
Background	Protein OS-9 is a protein that in humans is encoded by the OS9 gene. This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alteate transcriptional splice variants, encoding different isoforms, have been characterized.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-OS9 Antibody Picoband® catalog # A04158-1. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	s the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs
Host	Rabbit
Immunogen Region	E.coli-derived human OS9 recombinant protein (Position: Q56-E635).
Isotype	Rabbit IgG
Molecular Weight	83 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Eukaryotic peptide chain release factor subunit 1; Eukaryotic release factor 1; Erf1; Protein Cl1; TB3-1; ETF1; ERF1; RF1; SUP45L1
Tissue Specificity	Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q13438
Gene Id	10956
Gene Name	OS9
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J., Semenza, G. L. OS-9 interacts with hypoxia-inducible factor 1-alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1-alpha. Molec. Cell 17: 503-512, 2005. 2. Bhamidipati, A., Denic, V., Quan, E. M., Weissman, J. S. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Molec. Cell 19: 741-751, 2005. 3. Friedmann, E., Salzberg, Y., Weinberger, A., Shaltiel, S., Gerst, J. E. YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J. Biol. Chem. 277: 35274-35281, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003716-1	A04158-1	-	100 ug	$370		Add to Cart
BHA21003716-2	A04158-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003716-3	A04158-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003716-4	A04158-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003716-5	A04158-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003716-6	A04158-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003716-7	A04158-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003716-8	A04158-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003716-9	A04158-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003716-10	A04158-1-APC	APC	100 ug	$670		Add to Cart
BHA21003716-11	A04158-1-PE	PE	100 ug	$670		Add to Cart
BHA21003716-12	A04158-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003716-13	A04158-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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