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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ORP150/HYOU1 Antibody Picoband®

SKU : BHA21003574

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Mfr.No.	A04934-2, A04934-2-10ug, A04934-2-Biotin, A04934-2-Cy3, A04934-2-Dylight488, A04934-2-Dylight550, A04934-2-Dylight594, A04934-2-FITC, A04934-2-HRP, A04934-2-APC, A04934-2-PE, A04934-2-iFluor647, A04934-2-carrier-free
Alternative Names	REC8 meiotic recombination protein
Background	Hypoxia up-regulated protein 1 is a protein that in humans is encoded by the HYOU1 gene. The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alteative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alteative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ORP150/HYOU1 Antibody Picoband® catalog # A04934-2. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromer
Host	Rabbit
Immunogen Region	E.coli-derived human ORP150/HYOU1 recombinant protein (Position: K46-K913).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Meiotic recombination protein REC8 homolog; Cohesin Rec8p; REC8; REC8L1
Tissue Specificity	Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9Y4L1
Gene Id	10525
Gene Name	HYOU1
Subcellular Location	Nucleus. Chromosome. Centromere.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 1-2 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Haapaniemi, E. M., Fogarty, C. L., Keskitalo, S., Katayama, S., Vihinen, H., Ilander, M., Mustjoki, S., Krjutskov, K., Lehto, M., Hautala, T., Eriksson, O., Jokitalo, E., Velagapudi, V., Varjosalo, M., Seppanen, M., Kere, J. Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1. (Letter) J. Allergy Clin. Immun. 139: 1391-1393, 2017. 2. Ikeda, J., Kaneda, S., Kuwabara, K., Ogawa, S., Kobayashi, T., Matsumoto, M., Yura, T., Yanagi, H. Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150. Biochem. Biophys. Res. Commun. 230: 94-99, 1997. 3. Janeczko, K. The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain. Brain Res. 564: 86-90, 1991.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003574-1	A04934-2	-	100 ug	$370		Add to Cart
BHA21003574-2	A04934-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003574-3	A04934-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003574-4	A04934-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003574-5	A04934-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003574-6	A04934-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003574-7	A04934-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003574-8	A04934-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003574-9	A04934-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003574-10	A04934-2-APC	APC	100 ug	$670		Add to Cart
BHA21003574-11	A04934-2-PE	PE	100 ug	$670		Add to Cart
BHA21003574-12	A04934-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003574-13	A04934-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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