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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Orai1 Antibody Picoband®

SKU : BHA21002299

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Mfr.No.	A00909, A00909-10ug, A00909-Biotin, A00909-Cy3, A00909-Dylight488, A00909-Dylight550, A00909-Dylight594, A00909-FITC, A00909-HRP, A00909-APC, A00909-PE, A00909-iFluor647, A00909-carrier-free
Alternative Names	ORAI calcium release-activated calcium modulator 1
Background	ORAI1 (ORAI calcium release-activated calcium modulator 1), also known as CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, FLJ14466, is a calcium selectiveion channelthat in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans. The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers.Prakriya et al. showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments. Glu106-to-asp (E106D) and glu190-to-gln (E190Q) substitutions in transmembrane helices 1 and 3, respectively, diminished calcium ion influx, increased current carried by monovalent cations, and rendered the channel permeable to cesium ion.Prakriya et al. showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Orai1 Antibody catalog # A00909. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the
Host	Rabbit
Immunogen Region	E.coli-derived human Orai1 recombinant protein (Position: A49-A301).
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A; ORAI1; CRACM1; TMEM142A
Tissue Specificity	Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q96D31
Gene Id	84876
Gene Name	ORAI1
Subcellular Location	Cell membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.25-0.5ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A., Hogan, P. G. Orai1 is an essential pore subunit of the CRAC channel. Nature 443: 230-233, 2006.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002299-1	A00909	-	100 ug	$370		Add to Cart
BHA21002299-2	A00909-10ug	Sample	10 ug	$99		Add to Cart
BHA21002299-3	A00909-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002299-4	A00909-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002299-5	A00909-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002299-6	A00909-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002299-7	A00909-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002299-8	A00909-FITC	FITC	100 ug	$570		Add to Cart
BHA21002299-9	A00909-HRP	HRP	100 ug	$570		Add to Cart
BHA21002299-10	A00909-APC	APC	100 ug	$670		Add to Cart
BHA21002299-11	A00909-PE	PE	100 ug	$670		Add to Cart
BHA21002299-12	A00909-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002299-13	A00909-carrier-free	carrier-free	100 ug	$370		Add to Cart

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