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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Orai1 Antibody Picoband®

SKU : BHA21007118

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Mfr.No.	PA1857, PA1857-10ug, PA1857-Biotin, PA1857-Cy3, PA1857-Dylight488, PA1857-Dylight550, PA1857-Dylight594, PA1857-FITC, PA1857-HRP, PA1857-APC, PA1857-PE, PA1857-iFluor647, PA1857-carrier-free
Alternative Names	Calcium release-activated calcium channel protein 1
Background	ORAI1 (ORAI calcium release-activated calcium modulator 1), also known as CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, FLJ14466, is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans. The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers. Prakriya et al. (2006) showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments. Glu106-to-asp (E106D) and glu190-to-gln (E190Q) substitutions in transmembrane helices 1 and 3, respectively, diminished calcium ion influx, increased current carried by monovalent cations, and rendered the channel permeable to cesium ion. Prakriya et al. (2006) showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Orai1 Antibody catalog # PA1857. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Ca (2+) release-activated Ca (2+) (CRAC) channel subunit which mediates Ca (2+) influx following depletion of intracellular Ca (2+) stores and channel activation by the Ca (2+) sensor, STIM1. CRAC channels are the main pathway for Ca (2+) influx in T-cell
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Orai1, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Calcium release-activated calcium channel protein 1;Protein orai-1;Transmembrane protein 142A;ORAI1;CRACM1, TMEM142A;
Tissue Specificity	Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q96D31
Gene Name	ORAI1
Sequence	Belongs to the Orai family.
Subcellular Location	Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome . Isoform beta is more mobile in the plasma membrane. Colocalizes with UBQLN1 in the autophagosome. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A., Hogan, P. G. Orai1 is an essential pore subunit of the CRAC channel. Nature 443: 230-233, 2006.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007118-1	PA1857	-	100 ug	$370		Add to Cart
BHA21007118-2	PA1857-10ug	Sample	10 ug	$99		Add to Cart
BHA21007118-3	PA1857-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007118-4	PA1857-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007118-5	PA1857-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007118-6	PA1857-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007118-7	PA1857-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007118-8	PA1857-FITC	FITC	100 ug	$570		Add to Cart
BHA21007118-9	PA1857-HRP	HRP	100 ug	$570		Add to Cart
BHA21007118-10	PA1857-APC	APC	100 ug	$670		Add to Cart
BHA21007118-11	PA1857-PE	PE	100 ug	$670		Add to Cart
BHA21007118-12	PA1857-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007118-13	PA1857-carrier-free	carrier-free	100 ug	$370		Add to Cart

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