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Home / Primary Antibodies / Polyclonal Antibodies

Anti-OPA1 Antibody Picoband®

SKU : BHA21000629

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Mfr.No.	PB9731, PB9731-10ug, PB9731-Biotin, PB9731-Cy3, PB9731-Dylight488, PB9731-Dylight550, PB9731-Dylight594, PB9731-FITC, PB9731-HRP, PB9731-APC, PB9731-PE, PB9731-iFluor647, PB9731-carrier-free
Alternative Names	Dynamin-like 120 kDa protein, mitochondrial
Background	Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-OPA1 Antibody Picoband® catalog # PB9731. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of O
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human OPA1, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	80-100 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dynamin-like 120 kDa protein, mitochondrial;3.6.5.5;Optic atrophy protein 1;Dynamin-like 120 kDa protein, form S1;OPA1;KIAA0567;
Tissue Specificity	Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O60313
Gene Id	4976
Gene Name	OPA1
Subcellular Location	Mitochondrion inner membrane ; Single-pass membrane protein . Mitochondrion intermembrane space .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS (Nov 2014). "OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand". The EMBO Joual 33 (22): 267691. 2. Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V (Mar 2015). "OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation". Brain 138 (Pt 3): 56376.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000629-1	PB9731	100 ug	-	$370		Add to Cart
BHA21000629-2	PB9731-10ug	10 ug	Sample	$99		Add to Cart
BHA21000629-3	PB9731-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000629-4	PB9731-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000629-5	PB9731-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000629-6	PB9731-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000629-7	PB9731-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000629-8	PB9731-FITC	100 ug	FITC	$570		Add to Cart
BHA21000629-9	PB9731-HRP	100 ug	HRP	$570		Add to Cart
BHA21000629-10	PB9731-APC	100 ug	APC	$670		Add to Cart
BHA21000629-11	PB9731-PE	100 ug	PE	$670		Add to Cart
BHA21000629-12	PB9731-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000629-13	PB9731-carrier-free	100 ug	carrier-free	$370		Add to Cart

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