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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Oncostatin M/OSM Antibody Picoband®

SKU : BHA21006969

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Mfr.No.	PA1668, PA1668-10ug, PA1668-Biotin, PA1668-Cy3, PA1668-Dylight488, PA1668-Dylight550, PA1668-Dylight594, PA1668-FITC, PA1668-HRP, PA1668-APC, PA1668-PE, PA1668-iFluor647, PA1668-carrier-free
Alternative Names	Oncostatin-M
Background	OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Oncostatin M/OSM Antibody catalog # PA1668. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M.
Isotype	Rabbit IgG
Molecular Weight	28 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Oncostatin-M;OSM;OSM;
Tissue Specificity	Detected in neutrophils (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P13725
Gene Name	OSM
Sequence	Contains 1 FAD-binding FR-type domain.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Miles, S. A., Martinez-Maza, O., Rezai, A., Magpantay, L., Kishimoto, T., Nakamura, S., Radka, S. F., Linsley, P. S. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255: 1432-1434, 1992.<br /><br />2. Modur, V., Feldhaus, M. J., Weyrich, A. S., Jicha, D. L., Prescott, S. M., Zimmerman, G. A., McIntyre, T. M. Oncostatin M is a proinflammatory mediator: in vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. J. Clin. Invest. 100: 158-168, 1997.<br /><br />3. Rose, T. M., Bruce, A. G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Nat. Acad. Sci. 88: 8641-8645, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006969-1	PA1668	-	100 ug	$370		Add to Cart
BHA21006969-2	PA1668-10ug	Sample	10 ug	$99		Add to Cart
BHA21006969-3	PA1668-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006969-4	PA1668-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006969-5	PA1668-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006969-6	PA1668-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006969-7	PA1668-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006969-8	PA1668-FITC	FITC	100 ug	$570		Add to Cart
BHA21006969-9	PA1668-HRP	HRP	100 ug	$570		Add to Cart
BHA21006969-10	PA1668-APC	APC	100 ug	$670		Add to Cart
BHA21006969-11	PA1668-PE	PE	100 ug	$670		Add to Cart
BHA21006969-12	PA1668-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006969-13	PA1668-carrier-free	carrier-free	100 ug	$370		Add to Cart

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