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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Occludin/OCLN Antibody Picoband®

SKU : BHA21000175

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Mfr.No.	RP1057, RP1057-10ug, RP1057-Biotin, RP1057-Cy3, RP1057-Dylight488, RP1057-Dylight550, RP1057-Dylight594, RP1057-FITC, RP1057-HRP, RP1057-APC, RP1057-PE, RP1057-iFluor647, RP1057-carrier-free
Alternative Names	Occludin
Background	Occludin is an integral membrane protein that is located at tight junctions. It is a member of a family of proteins containing the highly conserved Marvel domain, which contains 4 transmembrane-helix regions. This gene is mapped to 5q13.2. Occludin regulates TGF-beta receptor type I localization for efficient TGF-beta-dependent dissolution of tight junctions during epithelial-mesenchymal transitions. Human Occludin is an essential hepatitis C virus (HCV) cell entry factor that is able to render murine cells infectable with HCV glycoproteins. It has been found that occludin is involved in cell migration and functions to recruit active PI3 kinase to the leading edge, resulting in RAC1 activation and formation of lamellipodia.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Occludin/OCLN Antibody catalog # RP1057. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. .
Host	Rabbit
Immunogen Region	E.coli-derived human Occludin recombinant protein (Position: N373-T522). Human Occludin shares 89% amino acid (aa) sequence identity with both mouse and rat Occludin.
Isotype	Rabbit IgG
Molecular Weight	59 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Occludin;OCLN;
Tissue Specificity	Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q16625
Gene Id	101000000
Gene Name	OCLN
Sequence	Belongs to the ELL/occludin family.
Subcellular Location	Membrane; Multi-pass membrane protein. Cell junction, tight junction.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Ando-Akatsuka, Y., Saitou, M., Hirase, T., Kishi, M., Sakakibara, A., Itoh, M., Yonemura, S., Furuse, M., Tsukita, S. Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J. Cell Biol. 133: 43-47, 1996. 2. Barrios-Rodiles, M., Brown, K. R., Ozdamar, B., Bose, R., Liu, Z., Donovan, R. S., Shinjo, F., Liu, Y., Dembowy, J., Taylor, I. W., Luga, V., Przulj, N., Robinson, M., Suzuki, H., Hayashizaki, Y., Jurisica, I., Wrana, J. L. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307: 1621-1625, 2005. 3. Du, D., Xu, F., Yu, L., Zhang, C., Lu, X., Yuan, H., Huang, Q., Zhang, F., Bao, H., Jia, L., Wu, X., Zhu, X., Zhang, X., Zhang, Z., Chen, Z. The tight junction protein, occludin, regulates the ional migration of epithelial cells. Dev. Cell 18: 52-63, 2010.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000175-1	RP1057	100 ug	-	$370		Add to Cart
BHA21000175-2	RP1057-10ug	10 ug	Sample	$99		Add to Cart
BHA21000175-3	RP1057-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000175-4	RP1057-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000175-5	RP1057-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000175-6	RP1057-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000175-7	RP1057-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000175-8	RP1057-FITC	100 ug	FITC	$570		Add to Cart
BHA21000175-9	RP1057-HRP	100 ug	HRP	$570		Add to Cart
BHA21000175-10	RP1057-APC	100 ug	APC	$670		Add to Cart
BHA21000175-11	RP1057-PE	100 ug	PE	$670		Add to Cart
BHA21000175-12	RP1057-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000175-13	RP1057-carrier-free	100 ug	carrier-free	$370		Add to Cart

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