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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NUMA/NUMA1 Antibody Picoband®

SKU : BHA21005506

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Mfr.No.	A02018-1, A02018-1-10ug, A02018-1-Biotin, A02018-1-Cy3, A02018-1-Dylight488, A02018-1-Dylight550, A02018-1-Dylight594, A02018-1-FITC, A02018-1-HRP, A02018-1-APC, A02018-1-PE, A02018-1-iFluor647, A02018-1-carrier-free
Alternative Names	tripartite motif containing 6
Background	Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene. This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NUMA/NUMA1 Antibody Picoband® catalog # A02018-1. Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells. Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and a
Host	Rabbit
Immunogen Region	E.coli-derived human NUMA/NUMA1 recombinant protein (Position: M1-E1954).
Isotype	Rabbit IgG
Molecular Weight	270 kDa
Reactivity	Human, Mouse, Rat, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Tripartite motif-containing protein 6; RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6; TRIM6; RNF89
Tissue Specificity	Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q14980
Gene Id	4926
Gene Name	NUMA1
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat, Monkey<br> Immunohistochemistry(Paraffin-embedded Section), 1-2 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Compton, D. A., Szilak, I., Cleveland, D. W. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J. Cell Biol. 116: 1395-1408, 1992. <br /><br />2. Lydersen, B. K., Pettijohn, D. E. Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell. Cell 22: 489-499, 1980. <br /><br />3. Merdes, A., Ramyar, K., Vechio, J. D., Cleveland, D. W. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 87: 447-458, 1996.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005506-1	A02018-1	-	100 ug	$370		Add to Cart
BHA21005506-2	A02018-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21005506-3	A02018-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005506-4	A02018-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005506-5	A02018-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005506-6	A02018-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005506-7	A02018-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005506-8	A02018-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21005506-9	A02018-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21005506-10	A02018-1-APC	APC	100 ug	$670		Add to Cart
BHA21005506-11	A02018-1-PE	PE	100 ug	$670		Add to Cart
BHA21005506-12	A02018-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005506-13	A02018-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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