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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NUDT5 Antibody Picoband®

SKU : BHA21005524

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Mfr.No.	A07530, A07530-10ug, A07530-Biotin, A07530-Cy3, A07530-Dylight488, A07530-Dylight550, A07530-Dylight594, A07530-FITC, A07530-HRP, A07530-APC, A07530-PE, A07530-iFluor647, A07530-carrier-free
Alternative Names	Formin-1
Background	ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene. This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NUDT5 Antibody Picoband® catalog # A07530. Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a role in the formation of adherens junction and the polymerization of linear actin cables. .
Host	Rabbit
Immunogen Region	E.coli-derived human NUDT5 recombinant protein (Position: M1-F219).
Isotype	Rabbit IgG
Molecular Weight	35 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Formin-1;Limb deformity protein homolog;FMN1;FMN, LD;
Tissue Specificity	Expressed ubiquitously.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9UKK9
Gene Id	11164
Gene Name	NUDT5
Subcellular Location	Nucleus . Cytoplasm . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Gasmi, L., Cartwright, J. L., McLennan, A. G. Cloning, expression and characterization of YSA1H, a human adenosine 5-prime-diphosphosugar pyrophosphatase possessing a MutT motif. Biochem. J. 344: 331-337, 1999.<br /><br />2. McLennan, A. G. The MutT family of nucleotide phosphohydrolases in man and human pathogens. Int. J. Molec. Med. 4: 79-89, 1999.<br /><br />3. Wright, R. H. G., Lioutas, A., Le Dily, F., Soronellas, D., Pohl, A., Bonet, J., Nacht, A. S., Samino, S., Font-Mateu, J., Vicent, G. P., Wierer, M., Trabado, M. A., Schelho, C., Carolis, C., Macias, M. J., Yanes, O., Oliva, B., Beato, M. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science 352: 1221-1225, 2016.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005524-1	A07530	-	100 ug	$370		Add to Cart
BHA21005524-2	A07530-10ug	Sample	10 ug	$99		Add to Cart
BHA21005524-3	A07530-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005524-4	A07530-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005524-5	A07530-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005524-6	A07530-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005524-7	A07530-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005524-8	A07530-FITC	FITC	100 ug	$570		Add to Cart
BHA21005524-9	A07530-HRP	HRP	100 ug	$570		Add to Cart
BHA21005524-10	A07530-APC	APC	100 ug	$670		Add to Cart
BHA21005524-11	A07530-PE	PE	100 ug	$670		Add to Cart
BHA21005524-12	A07530-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005524-13	A07530-carrier-free	carrier-free	100 ug	$370		Add to Cart

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