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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NTAL/LAT2 Antibody Picoband®

SKU : BHA21007256

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Mfr.No.	PA2039, PA2039-10ug, PA2039-Biotin, PA2039-Cy3, PA2039-Dylight488, PA2039-Dylight550, PA2039-Dylight594, PA2039-FITC, PA2039-HRP, PA2039-APC, PA2039-PE, PA2039-iFluor647, PA2039-carrier-free
Alternative Names	Linker for activation of T-cells family member 2
Background	LAT2 (Linker for Activation of T Cells Family, Member 2), also known as LAB or NTAL , is a protein that in humans is encoded by the LAT2 gene. By genomic sequence analysis, Doyle et al. (2000) mapped the WBSCR5 gene to chromosome 7q11.23. They noted that the flanking genes are highly conserved between mouse and human. By immunoprecipitation and immunoblot analysis, Brdicka et al. (2002) found that NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Janssen et al. (2003) determined that phosphorylation of LAB is likely mediated by SYK upon B-cell receptor stimulation. Binding analysis indicated associations with GRB2, and, inly, with PLCG1 and PLCG2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NTAL/LAT2 Antibody catalog # PA2039. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated s
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human NTAL.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Linker for activation of T-cells family member 2;Linker for activation of B-cells;Membrane-associated adapter molecule;Non-T-cell activation linker;Williams-Beuren syndrome chromosomal region 15 protein;Williams-Beuren syndrome chromosomal region 5 protein;LAT2;LAB, NTAL, WBS15, WBSCR15, WBSCR5;HSPC046;
Tissue Specificity	Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q9GZY6
Gene Name	LAT2
Sequence	Belongs to the peptidase S1 family. Kallikrein subfamily.
Subcellular Location	Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Brdicka, T., Imrich, M., Angelisova, P., Brdickova, N., Horvath, O., Spicka, J., Hilgert, I., Luskova, P., Draber, P., Novak, P., Engels, N., Wienands, J., Simeoni, L., Osterreicher, J., Aguado, E., Malissen, M., Schraven, B., Horejsi, V. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 1617-1626, 2002. <br /><br />2. Doyle, J. L., DeSilva, U., Miller, W., Green, E. D. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet. Cell Genet. 90: 285-290, 2000.<br /><br />3. Janssen, E., Zhu, M., Zhang, W., Koonpaew, S., Zhang, W. LAB: a new membrane-associated adaptor molecule in B cell activation. Nature Immun. 4: 117-123, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007256-1	PA2039	-	100 ug	$370		Add to Cart
BHA21007256-2	PA2039-10ug	Sample	10 ug	$99		Add to Cart
BHA21007256-3	PA2039-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007256-4	PA2039-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007256-5	PA2039-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007256-6	PA2039-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007256-7	PA2039-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007256-8	PA2039-FITC	FITC	100 ug	$570		Add to Cart
BHA21007256-9	PA2039-HRP	HRP	100 ug	$570		Add to Cart
BHA21007256-10	PA2039-APC	APC	100 ug	$670		Add to Cart
BHA21007256-11	PA2039-PE	PE	100 ug	$670		Add to Cart
BHA21007256-12	PA2039-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007256-13	PA2039-carrier-free	carrier-free	100 ug	$370		Add to Cart

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