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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NRG2 Antibody Picoband®

SKU : BHA21006946

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Mfr.No.	PA1637, PA1637-10ug, PA1637-Biotin, PA1637-Cy3, PA1637-Dylight488, PA1637-Dylight550, PA1637-Dylight594, PA1637-FITC, PA1637-HRP, PA1637-APC, PA1637-PE, PA1637-iFluor647, PA1637-carrier-free
Alternative Names	Pro-neuregulin-2, membrane-bound isoform
Background	Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NRG2 Antibody catalog # PA1637. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF re
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human NRG2, identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	91 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Pro-neuregulin-2, membrane-bound isoform;Pro-NRG2;Neuregulin-2;NRG-2;Divergent of neuregulin-1;DON-1;Neural- and thymus-derived activator for ERBB kinases;NTAK;NRG2;NTAK;
Tissue Specificity	Restricted to the cerebellum in the adult.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O14511
Gene Name	NRG2
Sequence	Belongs to the neuregulin family.
Subcellular Location	Pro-neuregulin-2, membrane-bound isoform: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Britto, J. M., Lukehurst, S., Weller, R., Fraser, C., Qiu, Y., Hertzog, P., Busfield, S. J. Generation and characterization of neuregulin-2-deficient mice. Molec. Cell. Biol. 24: 8221-8226, 2004.<br /><br />2. Burden, S., Yarden, Y. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18: 847-855, 1997.<br /><br />3. Chang H, Riese DJ, Gilbert W, Ste DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene".<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006946-1	PA1637	-	100 ug	$370		Add to Cart
BHA21006946-2	PA1637-10ug	Sample	10 ug	$99		Add to Cart
BHA21006946-3	PA1637-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006946-4	PA1637-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006946-5	PA1637-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006946-6	PA1637-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006946-7	PA1637-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006946-8	PA1637-FITC	FITC	100 ug	$570		Add to Cart
BHA21006946-9	PA1637-HRP	HRP	100 ug	$570		Add to Cart
BHA21006946-10	PA1637-APC	APC	100 ug	$670		Add to Cart
BHA21006946-11	PA1637-PE	PE	100 ug	$670		Add to Cart
BHA21006946-12	PA1637-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006946-13	PA1637-carrier-free	carrier-free	100 ug	$370		Add to Cart

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