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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NOTCH4 Antibody Picoband®

SKU : BHA21007095

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Mfr.No.	PA1831, PA1831-10ug, PA1831-Biotin, PA1831-Cy3, PA1831-Dylight488, PA1831-Dylight550, PA1831-Dylight594, PA1831-FITC, PA1831-HRP, PA1831-APC, PA1831-PE, PA1831-iFluor647, PA1831-carrier-free
Alternative Names	Neurogenic locus notch homolog protein 4
Background	NOTCH4 (NOTCH, DROSOPHILA, HOMOLOG OF, 4) also known as INT3 or NOTCH3, FORMERLY, is a member of the Notch family. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life, suggesting a specific role forNotch4 during development of vertebrate endothelium. The sequences of the mouse and human NOTCH4 proteins are 82% identical. Northe blot analysis revealed that NOTCH4 (S) is the major transcript and is expressed in a wide variety of tissues. Fluorescence in situ hybridization confirmed the location of the NOTCH4 gene at chromosome 6p21.3. In linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios, Wei and Hemmings (2000) found that NOTCH4 was highly associated with schizophrenia. Repression of Notch4 resolved ataxia and reversed the disease progression, demonstrating that Notch4 is not only sufficient to induce but also required to sustain the disease.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NOTCH4 Antibody catalog # PA1831. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human NOTCH4.
Isotype	Rabbit IgG
Molecular Weight	210 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Neurogenic locus notch homolog protein 4;Notch 4;hNotch4;Notch 4 extracellular truncation;Notch 4 intracellular domain;NOTCH4;INT3;
Tissue Specificity	Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q99466
Gene Name	NOTCH4
Sequence	Belongs to the NOTCH family.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Li, L., Huang, G. M., Banta, A. B., Deng, Y., Smith, T., Dong, P., Friedman, C., Chen, L., Trask, B. J., Spies, T., Rowen, L., Hood, L. Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene. Genomics 51: 45-58, 1998.<br /><br />2. Murphy, P. A., Lam, M. T. Y., Wu, X., Kim, T. N., Vartanian, S. M., Bollen, A. W., Carlson, T. R., Wang, R. A. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc. Nat. Acad. Sci. 105: 10901-10906, 2008. <br /><br />3. Wei, J., Hemmings, G. P. The NOTCH4 locus is associated with susceptibility to schizophrenia. (Letter) Nature Genet. 25: 376-377, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007095-1	PA1831	-	100 ug	$370		Add to Cart
BHA21007095-2	PA1831-10ug	Sample	10 ug	$99		Add to Cart
BHA21007095-3	PA1831-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007095-4	PA1831-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007095-5	PA1831-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007095-6	PA1831-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007095-7	PA1831-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007095-8	PA1831-FITC	FITC	100 ug	$570		Add to Cart
BHA21007095-9	PA1831-HRP	HRP	100 ug	$570		Add to Cart
BHA21007095-10	PA1831-APC	APC	100 ug	$670		Add to Cart
BHA21007095-11	PA1831-PE	PE	100 ug	$670		Add to Cart
BHA21007095-12	PA1831-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007095-13	PA1831-carrier-free	carrier-free	100 ug	$370		Add to Cart

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