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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NMDAR1/GRIN1 Antibody Picoband®

SKU : BHA21006686

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Mfr.No.	PA1222, PA1222-10ug, PA1222-Biotin, PA1222-Cy3, PA1222-Dylight488, PA1222-Dylight550, PA1222-Dylight594, PA1222-FITC, PA1222-HRP, PA1222-APC, PA1222-PE, PA1222-iFluor647, PA1222-carrier-free
Alternative Names	Glutamate receptor ionotropic, NMDA 1
Background	Glutamate (NMDA) receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene. The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and leaing. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alteatively spliced transcript variants have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NMDAR1/GRIN1 Antibody catalog # PA1222. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisit
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human NMDAR1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Glutamate receptor ionotropic, NMDA 1;GluN1;Glutamate (NMDA) receptor subunit zeta-1;N-methyl-D-aspartate receptor subunit NR1;NMD-R1;GRIN1;NMDAR1;
Tissue Specificity	Brain - muscle >> heart, kidney, lung, and trachea.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q05586
Gene Name	GRIN1
Sequence	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Subcellular Location	Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Enriched in postsynaptic plasma membrane and postsynaptic densities. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Karp, S. J.; Masu, M.; Eki, T.; Ozawa, K.; Nakanishi, S. : Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor. J. Biol. Chem. 268: 3728-3733, 1993. <br /><br />2. Zimmer, M.; Fink, T. M.; Franke, Y.; Lichter, P.; Spiess, J. : Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1). Gene 159: 219-223, 1995. <br /><br />3. Collins, C.; Duff, C.; Duncan, A. M. V.; Planells-Cases, R.; Sun, W.; Norremolle, A.; Michaelis, E.; Montal, M.; Worton, R.; Hayden, M. R. : Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. Genomics 17: 237-239, 1993. <br /><br />4. Takano, H.; Onodera, O.; Tanaka, H.; Mori, H.; Sakimura, K.; Hori, T.; Kobayashi, H.; Mishina, M.; Tsuji, S. : Chromosomal localization of the epsilon-1, epsilon-3, and zeta-1 subunit genes of the human NMDA receptor channel. Biochem. Biophys. Res. Commun. 197: 922-926, 1993.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006686-1	PA1222	-	100 ug	$370		Add to Cart
BHA21006686-2	PA1222-10ug	Sample	10 ug	$99		Add to Cart
BHA21006686-3	PA1222-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006686-4	PA1222-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006686-5	PA1222-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006686-6	PA1222-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006686-7	PA1222-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006686-8	PA1222-FITC	FITC	100 ug	$570		Add to Cart
BHA21006686-9	PA1222-HRP	HRP	100 ug	$570		Add to Cart
BHA21006686-10	PA1222-APC	APC	100 ug	$670		Add to Cart
BHA21006686-11	PA1222-PE	PE	100 ug	$670		Add to Cart
BHA21006686-12	PA1222-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006686-13	PA1222-carrier-free	carrier-free	100 ug	$370		Add to Cart

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