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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NM23A/NME1 Antibody Picoband®

SKU : BHA21000581

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Mfr.No.	RP1090, RP1090-10ug, RP1090-Biotin, RP1090-Cy3, RP1090-Dylight488, RP1090-Dylight550, RP1090-Dylight594, RP1090-FITC, RP1090-HRP, RP1090-APC, RP1090-PE, RP1090-iFluor647, RP1090-carrier-free
Alternative Names	Nucleoside diphosphate kinase A
Background	NME1 (NME/NM23 nucleoside diphosphate kinase 1), also called non-metastatic cells 1, protein (NM23A) expressed in, NM23, NM23-H1, NDPKA, GAAD or AWD, is an enzyme that in humans is encoded by the NME1 gene. The promoters of the mouse and human NME1 genes, like those of other NME genes, contain several binding sites for AP2, NF1, Sp1, LEF1, and response elements to glucocorticoid receptors. The NME1 gene is mapped on 17q21.33. Immunofluorescence microscopy demonstrated colocalization of NME1 in nuclei of B cells expressing EBNA3C. Expression of EBNA3C reversed the ability of NME1 to inhibit migration of BL and breast carcinoma cells. NM23H1 bound SET and was released from inhibition by GZMA cleavage of SET. After GZMA loading or cytotoxic T lymphocyte attack, SET and NM23H1 translocated to the nucleus and SET was degraded, allowing NM23H1 to nick chromosomal DNA. Using a Drosophila model system, Dammai et al. (2003) showed that the Drosophila NME1 homolog, awd, regulates trachea cell motility by modulating FGFR levels through a dynamin -mediated pathway.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NM23A/NME1 Antibody catalog # RP1090. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, s
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human NM23A, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	17 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nucleoside diphosphate kinase A;NDK A;NDP kinase A;2.7.4.6;Granzyme A-activated DNase;GAAD;Metastasis inhibition factor nm23;NM23-H1;Tumor metastatic process-associated protein;NME1;NDPKA, NM23;
Tissue Specificity	Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P15531
Gene Id	4830
Gene Name	NME1
Subcellular Location	Cytoplasm . Nucleus . Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Flow Cytometry(Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Chang, C. L., Zhu, X., Thoraval, D. H., Ungar, D., Rawwas, J., Hora, N., Strahler, J. R., Hanash, S. M., Radany, E. nm23-H1 mutation in neuroblastoma. (Letter) Nature 370: 335-336, 1994. 2. Dammai, V., Adryan, B., Lavenburg, K. R., Hsu, T. Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development. Genes Dev. 17: 2812-2824, 2003. 3. Dooley, S., Seib, T., Engel, M., Theisinger, B., Janz, H., Piontek, K., Zang, K.-D., Welter, C. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. Hum. Genet. 93: 63-66, 1994.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000581-1	RP1090	100 ug	-	$370		Add to Cart
BHA21000581-2	RP1090-10ug	10 ug	Sample	$99		Add to Cart
BHA21000581-3	RP1090-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000581-4	RP1090-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000581-5	RP1090-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000581-6	RP1090-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000581-7	RP1090-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000581-8	RP1090-FITC	100 ug	FITC	$570		Add to Cart
BHA21000581-9	RP1090-HRP	100 ug	HRP	$570		Add to Cart
BHA21000581-10	RP1090-APC	100 ug	APC	$670		Add to Cart
BHA21000581-11	RP1090-PE	100 ug	PE	$670		Add to Cart
BHA21000581-12	RP1090-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000581-13	RP1090-carrier-free	100 ug	carrier-free	$370		Add to Cart

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