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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NKCC1/SLC12A2 Antibody Picoband®

SKU : BHA21003447

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Mfr.No.	A03603, A03603-10ug, A03603-Biotin, A03603-Cy3, A03603-Dylight488, A03603-Dylight550, A03603-Dylight594, A03603-FITC, A03603-HRP, A03603-APC, A03603-PE, A03603-iFluor647, A03603-carrier-free
Alternative Names	protocadherin related 15
Background	Solute carrier family 12(sodium/potassium/chloride transporters), member 2, also known as NKCC1, is widely distributed throughout the body, especially in organs that secrete fluids, called exocrine glands. By fluorescence in situ hybridization, this gene is mapped to chromosome 5q23.3. The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NKCC1/SLC12A2 Antibody Picoband® catalog # A03603. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Host	Rabbit
Immunogen Region	E.coli-derived human NKCC1/SLC12A2 recombinant protein (Position: K889-K943).
Isotype	Rabbit IgG
Molecular Weight	180 kDa
Reactivity	Human, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Protocadherin-15; PCDH15; USH1F
Tissue Specificity	Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited patte of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P55011
Gene Id	6558
Gene Name	SLC12A2
Subcellular Location	Cell membrane. Single-pass type I. membrane protein. Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Dzhala, V. I., Talos, D. M., Sdrulla, D. A., Brumback, A. C., Mathews, G. C., Benke, T. A., Delpire, E., Jensen, F. E., Staley, K. J. NKCC1 transporter facilitates seizures in the developing brain. Nature Med. 11: 1205-1213, 2005.<br /><br />2. Nguyen, M., Pace, A. J., Koller, B. H. Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia. J. Exp. Med. 204: 1383-1393, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003447-1	A03603	-	100 ug	$370		Add to Cart
BHA21003447-2	A03603-10ug	Sample	10 ug	$99		Add to Cart
BHA21003447-3	A03603-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003447-4	A03603-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003447-5	A03603-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003447-6	A03603-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003447-7	A03603-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003447-8	A03603-FITC	FITC	100 ug	$570		Add to Cart
BHA21003447-9	A03603-HRP	HRP	100 ug	$570		Add to Cart
BHA21003447-10	A03603-APC	APC	100 ug	$670		Add to Cart
BHA21003447-11	A03603-PE	PE	100 ug	$670		Add to Cart
BHA21003447-12	A03603-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003447-13	A03603-carrier-free	carrier-free	100 ug	$370		Add to Cart

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