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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NF-kB p65/RELA Antibody Picoband®

SKU : BHA21007538

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Mfr.No.	PB9087, PB9087-10ug, PB9087-Biotin, PB9087-Cy3, PB9087-Dylight488, PB9087-Dylight550, PB9087-Dylight594, PB9087-FITC, PB9087-HRP, PB9087-APC, PB9087-PE, PB9087-iFluor647, PB9087-carrier-free
Alternative Names	Transcription factor p65
Background	Transcription factor p65, also known as NFKB3 or NF-kB p65, is a protein that in humans is encoded by the RELA gene. It is mapped to 11q13.1. NFKB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc, and it may play a role in inflammatory conditions of the peripheral nervous system. Phosphorylation and acetylation of NFKB3 are crucial post-translational modifications required for NFKB activation. It has also been shown to modulate immune responses, and activation of NFKB3 is positively associated with multiple types of cancer. In addition to that, NFKB3 antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NF-kB p65/RELA Antibody Picoband® catalog # PB9087. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immuni
Host	Rabbit
Immunogen Region	E.coli-derived human NF-kB p65 recombinant protein (Position: F99-S551). Human NF-kB p65 shares 86% amino acid (aa) sequence identity with mouse NF-kB p65.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Transcription factor p65;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;RELA;NFKB3;
Tissue Specificity	Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non- proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q04206
Gene Id	4790
Gene Name	RELA
Sequence	Contains 1 RHD (Rel-like) domain.
Subcellular Location	Nucleus. Cytoplasm. Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Nolan GP, Ghosh S, Liou HC, Tempst P, Baltimore D (April 1991). "DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide". Cell 64 (5): 9619. 2. Lim, C.-A., Yao, F., Wong, J. J.-Y., George, J., Xu, H., Chiu, K. P., Sung, W.-K., Lipovich, L., Vega, V. B., Chen, J., Shahab, A., Zhao, X. D., Hibberd, M., Wei, C.-L., Lim, B., Ng, H.-H., Ruan, Y., Chin, K.-C. Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappa-B upon TLR4 activation.Molec. Cell 27: 622-635, 2007. 3. Mazzeo, A., Aguennouz, M., Messina, C., Vita, G. Immunolocalization and activation of transcription factor nuclear factor kappa-B in dysimmune neuropathies and familial amyloidotic polyneuropathy. Arch. Neurol. 61: 1097-1102, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007538-1	PB9087	-	100 ug	$370		Add to Cart
BHA21007538-2	PB9087-10ug	Sample	10 ug	$99		Add to Cart
BHA21007538-3	PB9087-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007538-4	PB9087-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007538-5	PB9087-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007538-6	PB9087-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007538-7	PB9087-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007538-8	PB9087-FITC	FITC	100 ug	$570		Add to Cart
BHA21007538-9	PB9087-HRP	HRP	100 ug	$570		Add to Cart
BHA21007538-10	PB9087-APC	APC	100 ug	$670		Add to Cart
BHA21007538-11	PB9087-PE	PE	100 ug	$670		Add to Cart
BHA21007538-12	PB9087-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007538-13	PB9087-carrier-free	carrier-free	100 ug	$370		Add to Cart

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