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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NF-kB p65/RELA Antibody Picoband®

SKU : BHA21006970

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Mfr.No.	PA1669, PA1669-10ug, PA1669-Biotin, PA1669-Cy3, PA1669-Dylight488, PA1669-Dylight550, PA1669-Dylight594, PA1669-FITC, PA1669-HRP, PA1669-APC, PA1669-PE, PA1669-iFluor647, PA1669-carrier-free
Alternative Names	Transcription factor p65
Background	RELA (V-REL AVIAN RETICULOENDOTHELIOSIS VIRAL ONCOGENE HOMOLOG A), also called NFKB3 or NFKB, p65 SUBUNIT. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins, which inactivate NFKB by trapping it in the cytoplasm. The p65 (RELA) heterodimer is the most abundant form of NFKB. And the RELA gene is located on 11q13.1. RELA is a nonhistone substrate of HDAC3 and that IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes for subsequent NFKB responses. RELA nucleocytoplasmic redistribution coincided with export of PPARG, and immunoprecipitation analysis indicated that PPARG-RELA association was dependent on the PPARG C-terminal ligand-binding domain. IKK-dependent phosphorylation of RELA on ser468 enhanced binding of GCN5 to RELA and RELA ubiquitination.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NF-kB p65/RELA Antibody catalog # PA1669. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immuni
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human NF-kB p65, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	65-70 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Transcription factor p65;Nuclear factor NF-kappa-B p65 subunit;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;RELA;NFKB3;
Tissue Specificity	Detected in neutrophils (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q04206
Gene Name	RELA
Sequence	Contains 1 RHD (Rel-like) domain.
Subcellular Location	Nucleus. Cytoplasm. Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat <br>Immunocytochemistry/Immunofluorescence , 5ug/ml, Human, -<br>

Reference	1. Baeuerle, P. A. I-kappa-B--NF-kappa-B structures: at the interface of inflammation control. Cell 95: 729-731, 1998.<br /><br />2. Barken, D., Wang, C. J., Keas, J., Cheong, R., Hoffmann, A., Levchencko, A. Comment on 'Oscillations in NF-kappa-B signaling control the dynamics of gene expression.' (Commentary) Science 308: 52 only, 2005.<br /><br />3. Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., Baltimore, D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376: 167-170, 1995.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006970-1	PA1669	-	100 ug	$370		Add to Cart
BHA21006970-2	PA1669-10ug	Sample	10 ug	$99		Add to Cart
BHA21006970-3	PA1669-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006970-4	PA1669-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006970-5	PA1669-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006970-6	PA1669-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006970-7	PA1669-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006970-8	PA1669-FITC	FITC	100 ug	$570		Add to Cart
BHA21006970-9	PA1669-HRP	HRP	100 ug	$570		Add to Cart
BHA21006970-10	PA1669-APC	APC	100 ug	$670		Add to Cart
BHA21006970-11	PA1669-PE	PE	100 ug	$670		Add to Cart
BHA21006970-12	PA1669-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006970-13	PA1669-carrier-free	carrier-free	100 ug	$370		Add to Cart

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