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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Neurotrophin 4 (NT-4) Antibody

SKU : BHA21300796

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Alomone Labs

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Mfr.No.	ANT-004, ANT-004-CF_0.2 ml, ANT-004_0.2 ml, ANT-004_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Human
Background	The neurotrophins ("neuro" meaning nerve and "trophe" meaning nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and PNS.1 Neurotrophin-4 (NT-4) is expressed in neurons of the superior cervical, stellate and celiac ganglion,2 T-cells3 and is synthesized by keratinocytes.4 The structural hallmark of all neurotrophins is the characteristic arrangement of the disulfide bridges, known as the cysteine knot, which has been found in other growth factors such as PDGF.5 The rat and human forms of NT-4 are 96% homologous. NT-4 has been shown to promote dendritic outgrowth and calcium currents in cultured mesencephalic dopamine neurons,6 to promote growth and remodeling of adult motor neuron innervation,7 to be anterograde survival factors for postsynaptic cells8 and to protect against apoptotic neuronal death.9 The biological effects of NT-4 are mediated by two receptors: TrkB, which is specific for NT-4 and BDNF, and p75NTR, which binds all the neurotrophins.10
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of human Neurotrophin 4. Anti-Neurotrophin 4 (NT-4) Antibody (#ANT-004) can be used in western blot and immunohistochemistry applications. It has been designed to recognize NT-4 from rat, mouse and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Intracellular
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	NTF4, Neutrophic factor 4, Neurotrophin 5, NT-5, NTF5, Neutrophic factor 5, NT 4/5
UNSPSC Code	41116161
Note	Homology: Rat - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-NT004 Specifictiy: NTF4 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P34130
Gene Id	16485
Target	NTF4, Neutrophic factor 4, Neurotrophin 5, NT-5, NTF5, Neutrophic factor 5, NT 4/5
Sequence	LGEVPAAGGSPL(C), corresponding to amino acid residues 43-52 of mature human NT-4 (residues 123-132 of the precursor NT-4)

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300796-1	ANT-004-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300796-2	ANT-004_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300796-3	ANT-004_50 mcl	50 mcl	$697		Add to Cart

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