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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Neuropilin-2 NRP2 Antibody Picoband®

SKU : BHA21007042

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Mfr.No.	PA1771, PA1771-10ug, PA1771-Biotin, PA1771-Cy3, PA1771-Dylight488, PA1771-Dylight550, PA1771-Dylight594, PA1771-FITC, PA1771-HRP, PA1771-APC, PA1771-PE, PA1771-iFluor647, PA1771-carrier-free
Alternative Names	Neuropilin-2
Background	NRP2 (Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped on 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in Npn2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Neuropilin-2 NRP2 Antibody catalog # PA1771. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human NRP2, identical to the related mouse sequence and different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	105 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Neuropilin-2;Vascular endothelial cell growth factor 165 receptor 2;NRP2;VEGF165R2;
Tissue Specificity	In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O60462
Gene Name	NRP2
Sequence	Belongs to the neuropilin family.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Rat, Human, Mouse<br>

Reference	1. Chen, H., Bagri, A., Zupicich, J. A., Zou, Y., Stoeckli, E., Pleasure, S. J., Lowenstein, D. H., Skaes, W. C., Chedotal, A., Tessier-Lavigne, M.Neuropilin-2 regulates the development of select cranial and sensory nerves and hippocampal mossy fiber projections. Neuron 25: 43-56, 2000.<br /><br />2. Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., Heintz, N.A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature 425: 917-925, 2003.<br /><br />3. Rossignol, M., Beggs, A. H., Pierce, E. A., Klagsbrun, M. Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.Genomics 57: 459-460, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007042-1	PA1771	-	100 ug	$370		Add to Cart
BHA21007042-2	PA1771-10ug	Sample	10 ug	$99		Add to Cart
BHA21007042-3	PA1771-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007042-4	PA1771-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007042-5	PA1771-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007042-6	PA1771-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007042-7	PA1771-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007042-8	PA1771-FITC	FITC	100 ug	$570		Add to Cart
BHA21007042-9	PA1771-HRP	HRP	100 ug	$570		Add to Cart
BHA21007042-10	PA1771-APC	APC	100 ug	$670		Add to Cart
BHA21007042-11	PA1771-PE	PE	100 ug	$670		Add to Cart
BHA21007042-12	PA1771-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007042-13	PA1771-carrier-free	carrier-free	100 ug	$370		Add to Cart

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