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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Neuronal Pentraxin 2 (NPTX2) Antibody

SKU : BHA21300772

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Alomone Labs

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Mfr.No.	ANR-192, ANR-192-CF_0.2 ml, ANR-192_0.2 ml, ANR-192_25 mcl, ANR-192_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Mouse
Background	Neuronal pentraxin 2 (NP2), also known as NPTX2, NP-II, and neuronal activity-regulated pentraxin (Narp), is a calcium-dependent lectin secreted protein member of the pentraxin family involved in synaptic plasticity and excitatory homeostasis.1,2NP2 is part of the neuronal pentraxin family that includes two other members: Neuronal Pentraxin 1 (NP1) and Neuronal Pentraxin Receptor (NPTXR). The pentraxin superfamily members are arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain 2,3.NP2 is widely expressed in the brain, especially in the hippocampus, dentate gyrus, cerebellum, and cerebral cortex regions, as well as in the testis, pancreas, liver, heart, and skeletal muscle.2,3NP2 interacts with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which are crucial for excitatory neurotransmission in the brain. By binding to AMPA receptors, NP2 influences their trafficking and localization at synapses, affecting the strength of excitatory synaptic transmission 2,3.Given its presence in brain regions associated with learning and memory, alterations in NP2 levels or function have been implicated in cognitive processes. Dysregulation of NP2 has been observed in various neurological disorders, suggesting its potential importance in maintaining cognitive function.4-6Abnormalities in NP2 expression have been linked to neurodegenerative disorders, including Alzheimer's disease. Changes in NP2 levels may contribute to synaptic dysfunction and cognitive decline observed in these conditions.4-6
Clonality	Polyclonal
Description	Anti-Neuronal Pentraxin 2 (NPTX2) Antibody (#ANR-192) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPTX2 from rat, mouse and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Secreted
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP
UNSPSC Code	41116161
Note	Homology: Human - identical, rat - 12 out of 13 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-NR192 Specifictiy: NPTX2 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	O70340
Gene Id	53324
Target	Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP
Sequence	(C)HNETSAHRQKTES, corresponding to amino acid residues 186 - 198 of mouse NPTX2

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IHC, WB
Dilution	1:300

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300772-1	ANR-192-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21300772-2	ANR-192_0.2 ml	0.2 ml	$795		Add to Cart
BHA21300772-3	ANR-192_25 mcl	25 mcl	$597		Add to Cart
BHA21300772-4	ANR-192_50 mcl	50 mcl	$697		Add to Cart

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