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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Neurocan/NCAN Antibody Picoband®

SKU : BHA21001356

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Mfr.No.	A06700-1, A06700-1-10ug, A06700-1-Biotin, A06700-1-Cy3, A06700-1-Dylight488, A06700-1-Dylight550, A06700-1-Dylight594, A06700-1-FITC, A06700-1-HRP, A06700-1-APC, A06700-1-PE, A06700-1-iFluor647, A06700-1-carrier-free
Alternative Names	neurocan
Background	Neurocan core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but not with depressive symptoms. In the mice, the absence of functional Neurocan resulted in a variety of manic-like behaviors, which could be normalized by administering lithium.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Neurocan/NCAN Antibody Picoband® catalog # A06700-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Neurocan, which shares 90% amino acid (aa) sequence identity with both mouse and rat Neurocan.
Isotype	Rabbit IgG
Molecular Weight	200 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3, NEUR;
Tissue Specificity	Brain.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	NCAN: O14594
Gene Id	1463
Gene Name	NCAN
Subcellular Location	Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br>

Reference	1. Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". Am J Psychiatry. 169 (9): 98290.<br /><br />2. Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem. 267 (27): 1953647.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001356-1	A06700-1	100 ug	-	$370		Add to Cart
BHA21001356-2	A06700-1-10ug	10 ug	Sample	$99		Add to Cart
BHA21001356-3	A06700-1-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001356-4	A06700-1-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001356-5	A06700-1-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001356-6	A06700-1-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001356-7	A06700-1-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001356-8	A06700-1-FITC	100 ug	FITC	$570		Add to Cart
BHA21001356-9	A06700-1-HRP	100 ug	HRP	$570		Add to Cart
BHA21001356-10	A06700-1-APC	100 ug	APC	$670		Add to Cart
BHA21001356-11	A06700-1-PE	100 ug	PE	$670		Add to Cart
BHA21001356-12	A06700-1-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001356-13	A06700-1-carrier-free	100 ug	carrier-free	$370		Add to Cart

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