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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Netrin 1/NTN1 Antibody Picoband®

SKU : BHA21006965

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Mfr.No.	PA1662, PA1662-10ug, PA1662-Biotin, PA1662-Cy3, PA1662-Dylight488, PA1662-Dylight550, PA1662-Dylight594, PA1662-FITC, PA1662-HRP, PA1662-APC, PA1662-PE, PA1662-iFluor647, PA1662-carrier-free
Alternative Names	Netrin-1
Background	Netrin-1 (NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And netrin-1 expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1, and that netrin-1-dependent outgrowth of dorsal spinal cord axons ly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumor suppressors. Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro, whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Netrin 1/NTN1 Antibody catalog # PA1662. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its r
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Netrin 1, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	8 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Netrin-1;Epididymis tissue protein Li 131P;NTN1;NTN1L;
Tissue Specificity	Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O95631
Gene Name	NTN1
Sequence	Contains 3 laminin EGF-like domains.
Subcellular Location	Secreted, extracellular space, extracellular matrix .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Colon-Ramos, D. A., Margeta, M. A., Shen, K. Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Science 318: 103-106, 2007.<br /><br />2. Corset, V., Nguyen-Ba-Charvet, K. T., Forcet, C., Moyse, E., Chedotal, A., Mehlen, P. Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Nature 407: 747-750, 2000.<br /><br />3. Powell AW, Sassa T, Wu Y, Tessier-Lavigne M, Polleux F (May 2008). Ghosh, Anirvan. ed. "Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon." <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006965-1	PA1662	-	100 ug	$370		Add to Cart
BHA21006965-2	PA1662-10ug	Sample	10 ug	$99		Add to Cart
BHA21006965-3	PA1662-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006965-4	PA1662-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006965-5	PA1662-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006965-6	PA1662-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006965-7	PA1662-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006965-8	PA1662-FITC	FITC	100 ug	$570		Add to Cart
BHA21006965-9	PA1662-HRP	HRP	100 ug	$570		Add to Cart
BHA21006965-10	PA1662-APC	APC	100 ug	$670		Add to Cart
BHA21006965-11	PA1662-PE	PE	100 ug	$670		Add to Cart
BHA21006965-12	PA1662-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006965-13	PA1662-carrier-free	carrier-free	100 ug	$370		Add to Cart

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