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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Nephrin/NPHS1 Antibody Picoband®

SKU : BHA21001113

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Mfr.No.	A01991, A01991-10ug, A01991-Biotin, A01991-Cy3, A01991-Dylight488, A01991-Dylight550, A01991-Dylight594, A01991-FITC, A01991-HRP, A01991-APC, A01991-PE, A01991-iFluor647, A01991-carrier-free
Alternative Names	Nephrin
Background	NPHS1, also called Nephrin, is mapped to 19q13.12. This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. It gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. A defect in the gene for nephrin, NPHS1, is associated with congenital nephrotic syndrome of the Finnish type and causes massive amounts of protein to be leaked into the urine, orproteinuria. NPHS1 is also required for cardiovascular development.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Nephrin/NPHS1 Antibody Picoband® catalog # A01991. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation throug
Host	Rabbit
Immunogen Region	E.coli-derived human Nephrin recombinant protein (Position: V1084-V1241). Human Nephrin shares 79.9% and 75.3% amino acid (aa) sequence identity with mouse and rat Nephrin, respectively.
Isotype	Rabbit IgG
Molecular Weight	185 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Nephrin;Renal glomerulus-specific cell adhesion receptor;NPHS1;NPHN;
Tissue Specificity	Specifically expressed in podocytes of kidney glomeruli.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O60500
Gene Id	4868
Gene Name	NPHS1
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat

Reference	1. Wagner, N; Morrison, H; Pagnotta, S; Michiels, JF; Schwab, Y; Tryggvason, K; Schedl, A; Wagner, KD (2011-03-29). "The podocyte protein nephrin is required for cardiac vessel formation.". Human Molecular Genetics 20 (11): 218294.<br /><br />2. Wartiovaara, J., Ofverstedt, L.-G., Khoshnoodi, J., Zhang, J., Makela, E., Sandin, S., Ruotsalainen, V., Cheng, R. H., Jalanko, H., Skoglund, U., Tryggvason, K. Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. J. Clin. Invest. 114: 1475-1483, 2004. <br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001113-1	A01991	100 ug	-	$370		Add to Cart
BHA21001113-2	A01991-10ug	10 ug	Sample	$99		Add to Cart
BHA21001113-3	A01991-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001113-4	A01991-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001113-5	A01991-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001113-6	A01991-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001113-7	A01991-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001113-8	A01991-FITC	100 ug	FITC	$570		Add to Cart
BHA21001113-9	A01991-HRP	100 ug	HRP	$570		Add to Cart
BHA21001113-10	A01991-APC	100 ug	APC	$670		Add to Cart
BHA21001113-11	A01991-PE	100 ug	PE	$670		Add to Cart
BHA21001113-12	A01991-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001113-13	A01991-carrier-free	100 ug	carrier-free	$370		Add to Cart

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