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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NCX1/SLC8A1 Antibody Picoband®

SKU : BHA21005472

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Mfr.No.	A03876-2, A03876-2-10ug, A03876-2-Biotin, A03876-2-Cy3, A03876-2-Dylight488, A03876-2-Dylight550, A03876-2-Dylight594, A03876-2-FITC, A03876-2-HRP, A03876-2-APC, A03876-2-PE, A03876-2-iFluor647, A03876-2-carrier-free
Alternative Names	transient receptor potential cation channel subfamily V member 3
Background	In cardiac myocytes, Ca(2+) concentrations alteate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in retuing the cardiac myocyte to its resting state following excitation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NCX1/SLC8A1 Antibody Picoband® catalog # A03876-2. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectificati
Host	Rabbit
Immunogen Region	E.coli-derived human NCX1/SLC8A1 recombinant protein (Position: E301-Q686).
Isotype	Rabbit IgG
Molecular Weight	120 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3; TRPV3
Tissue Specificity	Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P32418
Gene Id	6546
Gene Name	SLC8A1
Subcellular Location	Membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	ELISA, IF, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Ebert, A. M., Hume, G. L., Warren, K. S., Cook, N. P., Bus, C. G., Mohideen, M. A., Siegal, G., Yelon, D., Fishman, M. C., Garrity, D. M. Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts. Proc. Nat. Acad. Sci. 102: 17705-17710, 2005.<br /><br />2. Hilge, M., Aelen, J., Vuister, G. W. Ca(2+) regulation in the Na(+)/Ca(2+) exchanger involves two markedly different Ca(2+) sensors. Molec. Cell 22: 15-25, 2006.<br /><br />3. Iwamoto, T., Kita, S., Zhang, J., Blaustein, M. P., Arai, Y., Yoshida, S., Wakimoto, K., Komuro, I., Katsuragi, T. Salt-sensitive hypertension is triggered by Ca(2+) entry via Na+/Ca+ exchanger type-1 in vascular smooth muscle. Nature Med. 10: 1193-1199, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005472-1	A03876-2	-	100 ug	$370		Add to Cart
BHA21005472-2	A03876-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005472-3	A03876-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005472-4	A03876-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005472-5	A03876-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005472-6	A03876-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005472-7	A03876-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005472-8	A03876-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005472-9	A03876-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005472-10	A03876-2-APC	APC	100 ug	$670		Add to Cart
BHA21005472-11	A03876-2-PE	PE	100 ug	$670		Add to Cart
BHA21005472-12	A03876-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005472-13	A03876-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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