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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NCOA2 Antibody Picoband®

SKU : BHA21006423

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Mfr.No.	A01706-2, A01706-2-10ug, A01706-2-Biotin, A01706-2-Cy3, A01706-2-Dylight488, A01706-2-Dylight550, A01706-2-Dylight594, A01706-2-FITC, A01706-2-HRP, A01706-2-APC, A01706-2-PE, A01706-2-iFluor647, A01706-2-carrier-free
Alternative Names	nuclear receptor coactivator 2
Background	The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NCOA2 Antibody Picoband® catalog # A01706-2. Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Host	Rabbit
Immunogen Region	E.coli-derived human NCOA2 recombinant protein (Position: E297-E1071). Human NCOA2 shares 93.4% and 90.8% amino acid (aa) sequence identity with mouse and rat NCOA2, respectively.
Isotype	Rabbit IgG
Molecular Weight	159 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	NCOA2; BHLHE75; SRC2; TIF2; Nuclear receptor coactivator 2; NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q15596
Gene Id	10499
Gene Name	NCOA2

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, FlowCytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunohistochemistry, 2-5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, Human

Reference	1. Aikawa, Y., Katsumoto, T., Zhang, P., Shima, H., Shino, M., Terui, K., Ito, E., Ohno, H., Stanley, E. R., Singh, H., Tenen, D. G., Kitabayashi, I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. (Letter) Nature Med. 16: 580-585, 2010. 2. Carapeti, M., Aguiar, R. C., Goldman, J. M., Cross, N. C. P. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. Blood 91: 3127-3133, 1998. 3. Chen, S. L., Dowhan, D. H., Hosking, B. M., Muscat, G. E. O. The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev. 14: 1209-1228, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006423-1	A01706-2	-	100 ug	$370		Add to Cart
BHA21006423-2	A01706-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21006423-3	A01706-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006423-4	A01706-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006423-5	A01706-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006423-6	A01706-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006423-7	A01706-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006423-8	A01706-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21006423-9	A01706-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21006423-10	A01706-2-APC	APC	100 ug	$670		Add to Cart
BHA21006423-11	A01706-2-PE	PE	100 ug	$670		Add to Cart
BHA21006423-12	A01706-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006423-13	A01706-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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