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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NCAM1 Antibody Picoband®

SKU : BHA21003199

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Mfr.No.	A00184-4, A00184-4-10ug, A00184-4-Biotin, A00184-4-Cy3, A00184-4-Dylight488, A00184-4-Dylight550, A00184-4-Dylight594, A00184-4-FITC, A00184-4-HRP, A00184-4-APC, A00184-4-PE, A00184-4-iFluor647, A00184-4-carrier-free
Alternative Names	neural cell adhesion molecule 1
Background	NCAM is a membrane-bound glycoprotein that plays a role in cell-cell and cell-matrix adhesion through both its homophilic and heterophilic binding activity. The neural cell adhesion molecule appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis. Later in development it is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle. NCAM gene is mapped to 11q23. The neural cell adhesion molecule (NCAM) can influence a number of diverse intercellular events, including junctional communication, the association of axons with pathways and targets, and signals that alter levels of neurotransmitter enzymes.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NCAM1 Antibody Picoband® catalog # A00184-4. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for rabies virus.
Host	Rabbit
Immunogen Region	E.coli-derived human NCAM1 recombinant protein (Position: T80-T328).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; CD56; NCAM1; NCAM
Tissue Specificity	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro- myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T- cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P13591
Gene Id	4684
Gene Name	NCAM1
Subcellular Location	Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Colocalizes with 14- 3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Nguyen, C.; Mattei, M. G.; Mattei, J.-F.; Santoni, M.-J.; Goridis, C.; Jordan, B. R. : Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11. J. Cell Biol. 102: 711-715, 1986. <br /><br />2. Telatar, M.; Lange, E.; Uhrhammer, N.; Gatti, R. A. : New localization of NCAM, proximal to DRD2 at chromosome 11q23. Mammalian Genome 6: 59-60, 1995. <br /><br />3. Rutishauser, U.; Acheson, A.; Hall, A. K.; Mann, D. M.; Sunshine, J. : The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Science 240: 53-57, 1988.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003199-1	A00184-4	-	100 ug	$370		Add to Cart
BHA21003199-2	A00184-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21003199-3	A00184-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003199-4	A00184-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003199-5	A00184-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003199-6	A00184-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003199-7	A00184-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003199-8	A00184-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21003199-9	A00184-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21003199-10	A00184-4-APC	APC	100 ug	$670		Add to Cart
BHA21003199-11	A00184-4-PE	PE	100 ug	$670		Add to Cart
BHA21003199-12	A00184-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003199-13	A00184-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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