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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NADPH oxidase 4/NOX4 Antibody Picoband®

SKU : BHA21007170

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Mfr.No.	PA1929, PA1929-10ug, PA1929-Biotin, PA1929-Cy3, PA1929-Dylight488, PA1929-Dylight550, PA1929-Dylight594, PA1929-FITC, PA1929-HRP, PA1929-APC, PA1929-PE, PA1929-iFluor647, PA1929-carrier-free
Alternative Names	NADPH oxidase 4
Background	NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-NADPH oxidase 4/NOX4 Antibody catalog # PA1929. Tested in Flow Cytometry, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potass
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse NADPH oxidase 4, identical to the related rat sequence and different from the related human sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	67 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NADPH oxidase 4;1.6.3.-;Kidney oxidase-1;KOX-1;Kidney superoxide-producing NADPH oxidase;Renal NAD (P)H-oxidase;Superoxide-generating NADPH oxidase 4;Nox4;Renox;
Tissue Specificity	EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon ho and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9JHI8
Gene Name	NOX4
Sequence	Contains 1 FAD-binding FR-type domain.
Subcellular Location	Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, focal adhesion . Cell membrane . May localize to plasma membrane and focal adhesions. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat, Human, Mouse, By Heat<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human<br> Immunocytochemistry, 0.5-1ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y. H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H., Iida, M. Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase. Circulation 109: 227-233, 2004.<br /><br />2. Geiszt, M., Kopp, J. B., Vaai, P., Leto, T. L. Identification of Renox, an NAD(P)H oxidase in kidney. Proc. Nat. Acad. Sci. 97: 8010-8014, 2000.<br /><br />3. Shiose, A., Kuroda, J., Tsuruya, K., Hirai, M., Hirakata, H., Naito, S., Hattori, M., Sakaki Y., Sumimoto, H. A novel superoxide-producing NAD(P)H oxidase in kidney. J. Biol. Chem. 276: 1417-1423, 2001.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007170-1	PA1929	-	100 ug	$370		Add to Cart
BHA21007170-2	PA1929-10ug	Sample	10 ug	$99		Add to Cart
BHA21007170-3	PA1929-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007170-4	PA1929-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007170-5	PA1929-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007170-6	PA1929-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007170-7	PA1929-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007170-8	PA1929-FITC	FITC	100 ug	$570		Add to Cart
BHA21007170-9	PA1929-HRP	HRP	100 ug	$570		Add to Cart
BHA21007170-10	PA1929-APC	APC	100 ug	$670		Add to Cart
BHA21007170-11	PA1929-PE	PE	100 ug	$670		Add to Cart
BHA21007170-12	PA1929-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007170-13	PA1929-carrier-free	carrier-free	100 ug	$370		Add to Cart

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