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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 Antibody Picoband®

SKU : BHA21002524

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Mfr.No.	A04081, A04081-10ug, A04081-Biotin, A04081-Cy3, A04081-Dylight488, A04081-Dylight550, A04081-Dylight594, A04081-FITC, A04081-HRP, A04081-APC, A04081-PE, A04081-iFluor647, A04081-carrier-free
Alternative Names	cholinergic receptor muscarinic 1
Background	The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 Antibody catalog # A04081. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi tu
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Muscarinic Acetylcholine Receptor 1/CHRM1, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Muscarinic acetylcholine receptor M1; CHRM1
Tissue Specificity	Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P11229
Gene Id	1128
Gene Name	CHRM1
Subcellular Location	Cell membrane. Multi-pass membrane protein. Postsynaptic cell membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Anagnostaras, S. G., Murphy, G. G., Hamilton, S. E., Mitchell, S. L., Rahnama, N. P., Nathanson, N. M., Silva, A. J. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nature Neurosci. 6: 51-58, 2003.<br /><br />2. Bonner, T. I., Buckley, N. J., Young, A. C., Brann, M. R. Identification of a family of muscarinic acetylcholine receptor genes. Science 237: 527-532, 1987. Note: Erratum: Science 237: 1556 only, 1987.<br /><br />3. Bonner, T. I., Modi, W. S., Seuanez, H. N., O'Brien, S. J. Chromosomal mapping of five human genes encoding muscarinic acetylcholine receptors. (Abstract) Cytogenet. Cell Genet. 58: 1850-1851, 1991.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002524-1	A04081	-	100 ug	$370		Add to Cart
BHA21002524-2	A04081-10ug	Sample	10 ug	$99		Add to Cart
BHA21002524-3	A04081-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002524-4	A04081-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002524-5	A04081-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002524-6	A04081-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002524-7	A04081-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002524-8	A04081-FITC	FITC	100 ug	$570		Add to Cart
BHA21002524-9	A04081-HRP	HRP	100 ug	$570		Add to Cart
BHA21002524-10	A04081-APC	APC	100 ug	$670		Add to Cart
BHA21002524-11	A04081-PE	PE	100 ug	$670		Add to Cart
BHA21002524-12	A04081-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002524-13	A04081-carrier-free	carrier-free	100 ug	$370		Add to Cart

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