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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MUM1/IRF4 Antibody Picoband®

SKU : BHA21000111

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Mfr.No.	PB9222, PB9222-10ug, PB9222-Biotin, PB9222-Cy3, PB9222-Dylight488, PB9222-Dylight550, PB9222-Dylight594, PB9222-FITC, PB9222-HRP, PB9222-APC, PB9222-PE, PB9222-iFluor647, PB9222-carrier-free
Alternative Names	Interferon regulatory factor 4
Background	Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MUM1/IRF4 Antibody Picoband® catalog # PB9222. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechan
Host	Rabbit
Immunogen Region	E.coli-derived human MUM1 recombinant protein (Position: E272-E451). Human MUM1 shares 92% amino acid (aa) sequence identity with mouse MUM1.
Isotype	Rabbit IgG
Molecular Weight	40 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interferon regulatory factor 4;IRF-4;Lymphocyte-specific interferon regulatory factor;LSIRF;Multiple myeloma oncogene 1;NF-EM5;IRF4;MUM1;
Tissue Specificity	Lymphoid cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q15306
Gene Id	3662
Gene Name	IRF4
Sequence	Belongs to the IRF family.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., Zeng, Y., Chen, B., Epstein, J., Staudt, L. M. IRF4 addiction in multiple myeloma. Nature 454: 226-231, 2008. 2. Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics 37 (2): 22933. 3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 66576.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000111-1	PB9222	100 ug	-	$370		Add to Cart
BHA21000111-2	PB9222-10ug	10 ug	Sample	$99		Add to Cart
BHA21000111-3	PB9222-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000111-4	PB9222-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000111-5	PB9222-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000111-6	PB9222-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000111-7	PB9222-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000111-8	PB9222-FITC	100 ug	FITC	$570		Add to Cart
BHA21000111-9	PB9222-HRP	100 ug	HRP	$570		Add to Cart
BHA21000111-10	PB9222-APC	100 ug	APC	$670		Add to Cart
BHA21000111-11	PB9222-PE	100 ug	PE	$670		Add to Cart
BHA21000111-12	PB9222-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000111-13	PB9222-carrier-free	100 ug	carrier-free	$370		Add to Cart

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