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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Mucin 5AC/MUC5AC Antibody Picoband®

SKU : BHA21007457

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Mfr.No.	PA2303, PA2303-10ug, PA2303-Biotin, PA2303-Cy3, PA2303-Dylight488, PA2303-Dylight550, PA2303-Dylight594, PA2303-FITC, PA2303-HRP, PA2303-APC, PA2303-PE, PA2303-iFluor647, PA2303-carrier-free
Alternative Names	Mucin-5AC
Background	Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD). It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a and critical mediator of resistance during intestinal nematode infection.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Mucin 5AC/MUC5AC Antibody catalog # PA2303. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Mucin 5AC.
Isotype	Rabbit IgG
Molecular Weight	300 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mucin-5AC ;MUC-5AC ;Gastric mucin ;Lewis B blood group antigen ;LeB ;Major airway glycoprotein ;Mucin-5 subtype AC, tracheobronchial;Tracheobronchial mucin ;TBM ;MUC5AC ;MUC5 ;
Tissue Specificity	Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P98088
Gene Name	MUC5AC
Sequence	Contains 1 CTCK (C-terminal cystine knot-like) domain.
Subcellular Location	Secreted .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>

Reference	1. Hasnain, S. Z., Evans, C. M., Roy, M., Gallagher, A. L., Kindrachuk, K. N., Barron, L., Dickey, B. F., Wilson, M. S., Wynn, T. A., Grencis, R. K., Thoton, D. J. Muc5ac: a critical component mediating the rejection of enteric nematodes. J. Exp. Med. 208: 893-900, 2011.<br /><br />2. Moehle, C., Ackermann, N., Langmann, T., Aslanidis, C., Kel, A., Kel-Margoulis, O., Schmitz-Madry, A., Zahn, A., Stremmel, W., Schmitz, G. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Molec. Med. 84: 1055-1066, 2006. <br /><br />3. Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med Genomics5 (1): 21.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007457-1	PA2303	-	100 ug	$370		Add to Cart
BHA21007457-2	PA2303-10ug	Sample	10 ug	$99		Add to Cart
BHA21007457-3	PA2303-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007457-4	PA2303-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007457-5	PA2303-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007457-6	PA2303-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007457-7	PA2303-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007457-8	PA2303-FITC	FITC	100 ug	$570		Add to Cart
BHA21007457-9	PA2303-HRP	HRP	100 ug	$570		Add to Cart
BHA21007457-10	PA2303-APC	APC	100 ug	$670		Add to Cart
BHA21007457-11	PA2303-PE	PE	100 ug	$670		Add to Cart
BHA21007457-12	PA2303-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007457-13	PA2303-carrier-free	carrier-free	100 ug	$370		Add to Cart

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