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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Mucin-1 MUC1 Antibody Picoband®

SKU : BHA21007456

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Mfr.No.	PA2302, PA2302-10ug, PA2302-Biotin, PA2302-Cy3, PA2302-Dylight488, PA2302-Dylight550, PA2302-Dylight594, PA2302-FITC, PA2302-HRP, PA2302-APC, PA2302-PE, PA2302-iFluor647, PA2302-carrier-free
Alternative Names	Mucin-1
Background	Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Mucin-1 MUC1 Antibody catalog # PA2302. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MUC1.
Isotype	Rabbit IgG
Molecular Weight	170 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mucin-1;MUC-1;Breast carcinoma-associated antigen DF3;Cancer antigen 15-3;CA 15-3;Carcinoma-associated mucin;Episialin;H23AG;Krebs von den Lungen-6;KL-6;PEMT;Peanut-reactive urinary mucin;PUM;Polymorphic epithelial mucin;PEM;Tumor-associated epithelial membrane antigen;EMA;Tumor-associated mucin;CD227;Mucin-1 subunit alpha;MUC1-NT;MUC1-alpha;Mucin-1 subunit beta;MUC1-beta;MUC1-CT;MUC1;PUM;
Tissue Specificity	Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P15941
Gene Name	Mucin 1
Sequence	Contains 1 SEA domain.
Subcellular Location	Apical cell membrane ; Single- pass type I membrane protein . Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, intealized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D (September 1990). "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin". J. Biol. Chem. 265 (25): 1528693.<br /><br />2. Wei, X., Xu, H., Kufe, D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Molec. Cell 21: 295-305, 2006. <br /><br />3. Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T., Kim, K. C. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J. Immun. 176: 3890-3894, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007456-1	PA2302	-	100 ug	$370		Add to Cart
BHA21007456-2	PA2302-10ug	Sample	10 ug	$99		Add to Cart
BHA21007456-3	PA2302-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007456-4	PA2302-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007456-5	PA2302-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007456-6	PA2302-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007456-7	PA2302-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007456-8	PA2302-FITC	FITC	100 ug	$570		Add to Cart
BHA21007456-9	PA2302-HRP	HRP	100 ug	$570		Add to Cart
BHA21007456-10	PA2302-APC	APC	100 ug	$670		Add to Cart
BHA21007456-11	PA2302-PE	PE	100 ug	$670		Add to Cart
BHA21007456-12	PA2302-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007456-13	PA2302-carrier-free	carrier-free	100 ug	$370		Add to Cart

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