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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MT2-MMP/MMP15 Antibody Picoband®

SKU : BHA21003197

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Mfr.No.	A06396-1, A06396-1-10ug, A06396-1-Biotin, A06396-1-Cy3, A06396-1-Dylight488, A06396-1-Dylight550, A06396-1-Dylight594, A06396-1-FITC, A06396-1-HRP, A06396-1-APC, A06396-1-PE, A06396-1-iFluor647, A06396-1-carrier-free
Alternative Names	Rho-related GTP-binding protein Rho6
Background	Matrix metalloproteinase 15 also known as MMP15 is an enzyme that in humans is encoded by the MMP15 gene. This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MT2-MMP/MMP15 Antibody Picoband® catalog # A06396-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Cause
Host	Rabbit
Immunogen Region	E.coli-derived human MT2-MMP/MMP15 recombinant protein (Position: Y132-A202).
Isotype	Rabbit IgG
Molecular Weight	74 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Rho-related GTP-binding protein Rho6;Rho family GTPase 1;Rnd1;RND1;RHO6;
Tissue Specificity	Mostly expressed in brain and liver.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P51511
Gene Id	4324
Gene Name	MMP15
Subcellular Location	Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Mattei, M.-G., Roeckel, N., Olsen, B. R., Apte, S. S. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. Genomics 40: 168-169, 1997. <br /><br />2. Sato, H., Tanaka, M., Takino, T., Inoue, M., Seiki, M. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. Genomics 39: 412-413, 1997. <br /><br />3. Takino, T., Sato, H., Shinagawa, A., Seiki, M. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library: MT-MMPs form a unique membrane-type subclass in the MMP family. J. Biol. Chem. 270: 23013-23020, 1995. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003197-1	A06396-1	-	100 ug	$370		Add to Cart
BHA21003197-2	A06396-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003197-3	A06396-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003197-4	A06396-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003197-5	A06396-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003197-6	A06396-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003197-7	A06396-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003197-8	A06396-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003197-9	A06396-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003197-10	A06396-1-APC	APC	100 ug	$670		Add to Cart
BHA21003197-11	A06396-1-PE	PE	100 ug	$670		Add to Cart
BHA21003197-12	A06396-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003197-13	A06396-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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