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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MSLNL Antibody Picoband®

SKU : BHA21005608

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Mfr.No.	A17693, A17693-10ug, A17693-Biotin, A17693-Cy3, A17693-Dylight488, A17693-Dylight550, A17693-Dylight594, A17693-FITC, A17693-HRP, A17693-APC, A17693-PE, A17693-iFluor647, A17693-carrier-free
Alternative Names	pyridine nucleotide-disulphide oxidoreductase domain 1
Background	Loss of gene function is implicated in the emergence of novel phenotypes during organism evolution. Human MSLNL has a nonsense mutation in exon 10 and two polymorphic mutations: a frameshift in exon 3 and a nonsense codon in exon 8. The gorilla gene also shows multiple deleterious mutations, including a premature stop codon, a deletion, and a splice site mutation. Molecular evolutionary analysis indicated relaxed selection pressure on MSLNL in African great ape lineages, which suggested that MSLNL might have become inactivated before the divergence of human, chimpanzee and gorilla. The mouse Mslnl gene is highly expressed in olfactory epithelium and moderately expressed in several other tissues. We propose that the loss of MSLNL may be associated with the evolution of the olfactory system in African great apes including human.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MSLNL Antibody Picoband® catalog # A17693. Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in cellular response to oxidative stress.
Host	Rabbit
Immunogen Region	E.coli-derived human MSLNL recombinant protein (Position: Q65-H423).
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; PYROXD1
Tissue Specificity	Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q96KJ4
Gene Id	401827
Gene Name	MSLNL
Subcellular Location	Nucleus. Sarcomere.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry, 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. B, D. W. K. A. , C, S. J. , A, D. S. K. , D, H. S. K. , A, S. B. S. , & A, Y. H. . (2012). Inactivation of the mslnl gene encoding mesothelin-like protein during african great ape evolution. Gene, 496( 1), 17-21.<br /><br />2. Hollevoet, K. , Nackaerts, K. , Gosselin, R. , Wever, W. D. , & Meerbeeck, J. P. V. . (2011). Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. Joual of Thoracic Oncology, 6(11), 1930-1937.<br /><br />3. Daniels, R. J. , Peden, J. F. , Lloyd, C. , Horsley, S. W. , & Higgs, D. R. . (2001). Sequence, structure and pathology of the fully annotated terminal 2 mb of the short arm of human chromosome 16. Human Molecular Genetics, 10(4), 339-352.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005608-1	A17693	-	100 ug	$370		Add to Cart
BHA21005608-2	A17693-10ug	Sample	10 ug	$99		Add to Cart
BHA21005608-3	A17693-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005608-4	A17693-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005608-5	A17693-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005608-6	A17693-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005608-7	A17693-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005608-8	A17693-FITC	FITC	100 ug	$570		Add to Cart
BHA21005608-9	A17693-HRP	HRP	100 ug	$570		Add to Cart
BHA21005608-10	A17693-APC	APC	100 ug	$670		Add to Cart
BHA21005608-11	A17693-PE	PE	100 ug	$670		Add to Cart
BHA21005608-12	A17693-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005608-13	A17693-carrier-free	carrier-free	100 ug	$370		Add to Cart

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