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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MSK1/RPS6KA5 Antibody Picoband®

SKU : BHA21000157

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Mfr.No.	PB9268, PB9268-10ug, PB9268-Biotin, PB9268-Cy3, PB9268-Dylight488, PB9268-Dylight550, PB9268-Dylight594, PB9268-FITC, PB9268-HRP, PB9268-APC, PB9268-PE, PB9268-iFluor647, PB9268-carrier-free
Alternative Names	Ribosomal protein S6 kinase alpha-5
Background	Ribosomal protein S6 kinase alpha-5, also known as MSK1, is an enzyme that in humans is encoded by the RPS6KA5 gene. It belongs to the AGC family of kinases. MSK1 gene is mapped to chromosome 14q31-q32. Northe blot analysis indicated that MSK1 was expressed as a 4-kb mRNA in all tissues tested, with the highest levels of expression in brain, muscle, and placenta. MSK1 was activated in vitro and in vivo by either ERK or SAPK2 proteins. It has been found that MSK1, rather than MAPKAP-K1 or MAPKAP-K2/K3, mediates activation of the cAMP response element-binding protein and activating transcription factor-1 by either growth factors or stress signals.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MSK1/RPS6KA5 Antibody Picoband® catalog # PB9268. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene acti
Host	Rabbit
Immunogen Region	E.coli-derived human MSK1 recombinant protein (Position: V540-Q665). Human MSK1 shares 98% amino acid (aa) sequence identity with mouse MSK1.
Isotype	Rabbit IgG
Molecular Weight	90 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Ribosomal protein S6 kinase alpha-5;S6K-alpha-5;2.7.11.1;90 kDa ribosomal protein S6 kinase 5;Nuclear mitogen- and stress-activated protein kinase 1;RSK-like protein kinase;RSKL;RPS6KA5;MSK1;
Tissue Specificity	Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O75582
Gene Id	9252
Gene Name	RPS6KA5
Sequence	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Subcellular Location	Nucleus. Cytoplasm. Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry , 0.5-1ug/ml, Human, - Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Deak, M., Clifton, A. D., Lucocq, J. M., Alessi, D. R. Mitogen- and stress-activated protein kinase-1 (MSK1) is ly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17: 4426-4441, 1998. 2. Jiang, C., Yu, L., Tu, Q., Zhao, Y., Zhang, H., Zhao, S. Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-q32.1 by radiation hybrid mapping. Cytogenet. Cell Genet. 87: 261-261, 1999.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000157-1	PB9268	100 ug	-	$370		Add to Cart
BHA21000157-2	PB9268-10ug	10 ug	Sample	$99		Add to Cart
BHA21000157-3	PB9268-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000157-4	PB9268-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000157-5	PB9268-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000157-6	PB9268-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000157-7	PB9268-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000157-8	PB9268-FITC	100 ug	FITC	$570		Add to Cart
BHA21000157-9	PB9268-HRP	100 ug	HRP	$570		Add to Cart
BHA21000157-10	PB9268-APC	100 ug	APC	$670		Add to Cart
BHA21000157-11	PB9268-PE	100 ug	PE	$670		Add to Cart
BHA21000157-12	PB9268-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000157-13	PB9268-carrier-free	100 ug	carrier-free	$370		Add to Cart

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