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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MSH6 Antibody Picoband®

SKU : BHA21002846

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Mfr.No.	A00553-2, A00553-2-10ug, A00553-2-Biotin, A00553-2-Cy3, A00553-2-Dylight488, A00553-2-Dylight550, A00553-2-Dylight594, A00553-2-FITC, A00553-2-HRP, A00553-2-APC, A00553-2-PE, A00553-2-iFluor647, A00553-2-carrier-free
Alternative Names	UDP-galactose-4-epimerase
Background	MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a biional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MSH6 Antibody Picoband® catalog # A00553-2. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MSH6, which shares 100% and 85.7% amino acid (aa) sequence identity with mouse and rat MSH6, respectively.
Isotype	Rabbit IgG
Molecular Weight	160 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	UDP-glucose 4-epimerase
Tissue Specificity	Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P52701
Gene Id	2956
Gene Name	MSH6
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ICC, IF, Flow Cytometry
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Kariola, R., Raevaara, T. E., Lonnqvist, K. E., Nystrom-Lahti, M. Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome. Hum. Molec. Genet. 11: 1303-1310, 2002. <br /><br />2. Verma, L., Kane, M. F., Brassett, C., Schmeits, J., Evans, D. G. R., Kolodner, R. D., Maher, E. R. Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer. J. Med. Genet. 36: 678-682, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002846-1	A00553-2	-	100 ug	$370		Add to Cart
BHA21002846-2	A00553-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002846-3	A00553-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002846-4	A00553-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002846-5	A00553-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002846-6	A00553-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002846-7	A00553-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002846-8	A00553-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002846-9	A00553-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002846-10	A00553-2-APC	APC	100 ug	$670		Add to Cart
BHA21002846-11	A00553-2-PE	PE	100 ug	$670		Add to Cart
BHA21002846-12	A00553-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002846-13	A00553-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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