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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MPG Antibody Picoband®

SKU : BHA21007090

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Mfr.No.	PA1825, PA1825-10ug, PA1825-Biotin, PA1825-Cy3, PA1825-Dylight488, PA1825-Dylight550, PA1825-Dylight594, PA1825-FITC, PA1825-HRP, PA1825-APC, PA1825-PE, PA1825-iFluor647, PA1825-carrier-free
Alternative Names	DNA-3-methyladenine glycosylase
Background	MPG (N-methylpurine-DNA glycosylase) also known as MDG, 3-METHYLADENINE DNA GLYCOSYLASE, 3MeAde DNA GLYCOSYLASE, AAG or APNG. The MPG gene is mapped to human chromosome 16 by analysis of a panel of DNAs from mouse/human and hamster/human hybrid cell lines. The MPG gene was expressed in all cell lines and tissues examined, but was found at particularly high levels in a colon adenocarcinoma cell line (HT29). The completely characterized human MPG gene was found to span 7 to 8 kb of genomic DNA and to be localized 75 kb upstream of the embryonic zeta-globin gene. To assess the contribution of Apng to the repair of several mutagenic lesions in vivo, Hang et al. (1997) biochemically analyzed cell-free extracts of tissues from mice with a targeted deletion of the Apng gene. Following treatment with DNA-methylating agents, increased persistence of 7-methylguanine (meG) was found in liver sections of APNG knockout mice in comparison with wildtype mice, demonstrating an in vivo phenotype for the APNG-null animals.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MPG Antibody catalog # PA1825. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MPG, different from the related mouse sequence by two amino acids, and from related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	DNA-3-methyladenine glycosylase;3.2.2.21;3-alkyladenine DNA glycosylase;3-methyladenine DNA glycosidase;ADPG;N-methylpurine-DNA glycosylase;MPG;AAG, ANPG, MID1;
Tissue Specificity	Expressed in breast, ovary and prostate.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P29372
Gene Name	MPG
Sequence	Belongs to the DNA glycosylase MPG family.
Subcellular Location	Cytoplasm . Mitochondrion matrix, mitochondrion nucleoid . Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Boosalis, M., Derfler, B., Call, K., Samson, L. Cloning of a human 3-methyladenine DNA glycosylase cDNA whose gene maps to human chromosome 16. (Abstract) Am. J. Hum. Genet. 49 (suppl.): 399 only, 1991.<br /><br />2. Engelward, B. P., Weeda, G., Wyatt, M. D., Broekhof, J. L. M., de Wit, J., Donker, I., Allan, J. M., Gold, B., Hoeijmakers, J. H. J., Samson, L. D.Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase. Proc. Nat. Acad. Sci. 94: 13087-13092, 1997.<br /><br />3. Kielman, M. F., Smits, R., Beini, L. F. Localization and characterization of the mouse alpha-globin locus control region. Genomics 21: 431-433, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007090-1	PA1825	-	100 ug	$370		Add to Cart
BHA21007090-2	PA1825-10ug	Sample	10 ug	$99		Add to Cart
BHA21007090-3	PA1825-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007090-4	PA1825-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007090-5	PA1825-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007090-6	PA1825-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007090-7	PA1825-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007090-8	PA1825-FITC	FITC	100 ug	$570		Add to Cart
BHA21007090-9	PA1825-HRP	HRP	100 ug	$570		Add to Cart
BHA21007090-10	PA1825-APC	APC	100 ug	$670		Add to Cart
BHA21007090-11	PA1825-PE	PE	100 ug	$670		Add to Cart
BHA21007090-12	PA1825-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007090-13	PA1825-carrier-free	carrier-free	100 ug	$370		Add to Cart

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