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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MLC1 Antibody Picoband®

SKU : BHA21002764

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Mfr.No.	A02920-1, A02920-1-10ug, A02920-1-Biotin, A02920-1-Cy3, A02920-1-Dylight488, A02920-1-Dylight550, A02920-1-Dylight594, A02920-1-FITC, A02920-1-HRP, A02920-1-APC, A02920-1-PE, A02920-1-iFluor647, A02920-1-carrier-free
Alternative Names	Tubby protein homolog
Background	The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alteatively spliced transcript variants encoding different isoforms have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MLC1 Antibody Picoband® catalog # A02920-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be invo
Host	Rabbit
Immunogen Region	E.coli-derived human MLC1 recombinant protein (Position: M1-Q377).
Isotype	Rabbit IgG
Molecular Weight	41 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Tubby protein homolog;TUB;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	Q15049
Gene Id	23209
Gene Name	MLC1
Subcellular Location	Cytoplasm . Nucleus . Secreted . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G (q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Duarri, A., Teijido, O., Lopez-Heandez, T., Scheper, G. C., Barriere, H., Boor, I., Aguado, F., Zorzano, A., Palacin, M., Martinez, A., Lukacs, G. L., van der Knaap, M. S., Nunes, V., Estevez, R. Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects. Hum. Molec. Genet. 17: 3728-3739, 2008.<br /><br />2. Ilja Boor, P. K., de Groot, K., Mejaski-Bosnjak, V., Brenner, C., van der Knaap, M. S., Scheper, G. C., Pronk, J. C. Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1. Hum. Mutat. 27: 505-512, 2006. <br /><br />3. Leegwater, P. A. J., Boor, P. K. I., Yuan, B. Q., van der Steen, J., Visser, A., Konst, A. A. M., Oudejans, C. B. M., Schutgens, R. B. H., Pronk, J. C., van der Knaap, M. S. Identification of novel mutations in MLC1 responsible for megalencephalic leukoencephalopathy with subcortical cysts. Hum. Genet. 110: 279-283, 2002. Note: Erratum: Hum. Genet. 111: 114 only, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002764-1	A02920-1	-	100 ug	$370		Add to Cart
BHA21002764-2	A02920-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002764-3	A02920-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002764-4	A02920-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002764-5	A02920-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002764-6	A02920-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002764-7	A02920-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002764-8	A02920-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002764-9	A02920-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002764-10	A02920-1-APC	APC	100 ug	$670		Add to Cart
BHA21002764-11	A02920-1-PE	PE	100 ug	$670		Add to Cart
BHA21002764-12	A02920-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002764-13	A02920-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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