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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband®

SKU : BHA21000667

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Mfr.No.	PB9765, PB9765-10ug, PB9765-Biotin, PB9765-Cy3, PB9765-Dylight488, PB9765-Dylight550, PB9765-Dylight594, PB9765-FITC, PB9765-HRP, PB9765-APC, PB9765-PE, PB9765-iFluor647, PB9765-carrier-free
Alternative Names	Mineralocorticoid receptor
Background	NR3C2 (nuclear receptor subfamily 3, group C, member 2), also known as MR (mineralocorticoid receptor), is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Mineralocorticoid Receptor/NR3C2 Antibody Picoband® catalog # PB9765. Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water tr
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mineralocorticoid receptor;MR;Nuclear receptor subfamily 3 group C member 2;NR3C2;MCR, MLR;
Tissue Specificity	Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P08235
Gene Id	4306
Gene Name	NR3C2
Subcellular Location	Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human

Reference	1. Fan YS, Eddy RL, Byers MG, Haley LL, Henry WM, Nowak NJ, Shows TB (1989). "The human mineralocorticoid receptor gene (MLR) is located on chromosome 4 at q31.2". Cytogenet. Cell Genet.52 (1-2): 834. 2. Zennaro MC, Souque A, Viengchareun S, Poisson E, Lombès M (September 2001). "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action". Mol. Endocrinol. 15 (9): 158698.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000667-1	PB9765	100 ug	-	$370		Add to Cart
BHA21000667-2	PB9765-10ug	10 ug	Sample	$99		Add to Cart
BHA21000667-3	PB9765-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000667-4	PB9765-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000667-5	PB9765-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000667-6	PB9765-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000667-7	PB9765-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000667-8	PB9765-FITC	100 ug	FITC	$570		Add to Cart
BHA21000667-9	PB9765-HRP	100 ug	HRP	$570		Add to Cart
BHA21000667-10	PB9765-APC	100 ug	APC	$670		Add to Cart
BHA21000667-11	PB9765-PE	100 ug	PE	$670		Add to Cart
BHA21000667-12	PB9765-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000667-13	PB9765-carrier-free	100 ug	carrier-free	$370		Add to Cart

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