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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Metalloproteinase inhibitor 3 TIMP3 Antibody Picoband®

SKU : BHA21006656

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Mfr.No.	PA1077, PA1077-10ug, PA1077-Biotin, PA1077-Cy3, PA1077-Dylight488, PA1077-Dylight550, PA1077-Dylight594, PA1077-FITC, PA1077-HRP, PA1077-APC, PA1077-PE, PA1077-iFluor647, PA1077-carrier-free
Alternative Names	Metalloproteinase inhibitor 3
Background	Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. It is mapped to 22q12.1-q13.2. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of theextracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Metalloproteinase inhibitor 3 TIMP3 Antibody catalog # PA1077. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MM
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP3, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	91 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Metalloproteinase inhibitor 3;Protein MIG-5;Tissue inhibitor of metalloproteinases 3;TIMP-3;TIMP3;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P35625
Gene Name	TIMP3
Sequence	Belongs to the protease inhibitor I35 (TIMP) family.
Subcellular Location	Secreted, extracellular space, extracellular matrix.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	ELISA, 0.1-0.5ug/ml, -<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)".<br /><br />2. Apte, S. S.; Mattei, M.-G.; Olsen, B. R. : Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 19: 86-90, 1994. <br /><br />3. Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med 9 (4): 40715.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006656-1	PA1077	-	100 ug	$370		Add to Cart
BHA21006656-2	PA1077-10ug	Sample	10 ug	$99		Add to Cart
BHA21006656-3	PA1077-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006656-4	PA1077-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006656-5	PA1077-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006656-6	PA1077-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006656-7	PA1077-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006656-8	PA1077-FITC	FITC	100 ug	$570		Add to Cart
BHA21006656-9	PA1077-HRP	HRP	100 ug	$570		Add to Cart
BHA21006656-10	PA1077-APC	APC	100 ug	$670		Add to Cart
BHA21006656-11	PA1077-PE	PE	100 ug	$670		Add to Cart
BHA21006656-12	PA1077-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006656-13	PA1077-carrier-free	carrier-free	100 ug	$370		Add to Cart

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