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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Melanoma gp100/PMEL Antibody Picoband®

SKU : BHA21002064

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Mfr.No.	A01262-1, A01262-1-10ug, A01262-1-Biotin, A01262-1-Cy3, A01262-1-Dylight488, A01262-1-Dylight550, A01262-1-Dylight594, A01262-1-FITC, A01262-1-HRP, A01262-1-APC, A01262-1-PE, A01262-1-iFluor647, A01262-1-carrier-free
Alternative Names	premelanosome protein
Background	This gene is mapped to 12q13.2. It encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating inteal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex patte of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alteate splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Melanoma gp100/PMEL Antibody Picoband® catalog # A01262-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distin
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Melanoma gp100/PMEL, which shares 71.4% and 65.7% amino acid (aa) sequence identity with mouse and rat Melanoma gp100/PMEL, respectively.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Melanocyte protein PMEL; ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homolog; M-alpha; 95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen; ME20-S; ME20S; M-beta; PMEL; D12S53E; PMEL17; SILV
Tissue Specificity	Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P40967
Gene Id	6490
Gene Name	PMEL
Subcellular Location	multivesicular body. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Golgi apparatus. Melanosome. Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml<br>

Reference	1. Adema, G. J., de Boer, A. J., Vogel, A. M., Loenen, W. A. M., Figdor, C. G. Molecular characterization of the melanocyte lineage-specific antigen gp100. J. Biol. Chem. 269: 20126-20133, 1994. <br /><br />2. Bailin, T., Lee, S.-T., Spritz, R. A. Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus. J. Invest. Derm. 106: 24-27, 1996. <br /><br />3. Berson, J. F., Harper, D. C., Tenza, D., Raposo, G., Marks, M. S. Pmel17 initiates premelanosome morphogenesis within multivesicular bodies. Molec. Biol. Cell 12: 3451-3464, 2001.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002064-1	A01262-1	-	100 ug	$370		Add to Cart
BHA21002064-2	A01262-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002064-3	A01262-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002064-4	A01262-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002064-5	A01262-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002064-6	A01262-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002064-7	A01262-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002064-8	A01262-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002064-9	A01262-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002064-10	A01262-1-APC	APC	100 ug	$670		Add to Cart
BHA21002064-11	A01262-1-PE	PE	100 ug	$670		Add to Cart
BHA21002064-12	A01262-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002064-13	A01262-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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