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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MEKK2/MAP3K2 Antibody Picoband®

SKU : BHA21006842

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Mfr.No.	PA1499, PA1499-10ug, PA1499-Biotin, PA1499-Cy3, PA1499-Dylight488, PA1499-Dylight550, PA1499-Dylight594, PA1499-FITC, PA1499-HRP, PA1499-APC, PA1499-PE, PA1499-iFluor647, PA1499-carrier-free
Alternative Names	Mitogen-activated protein kinase kinase kinase 2
Background	MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase (MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the Inteational Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MEKK2/MAP3K2 Antibody catalog # PA1499. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK2, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	78 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mitogen-activated protein kinase kinase kinase 2;2.7.11.25;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2;MAP3K2;MAPKKK2, MEKK2;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9Y2U5
Gene Name	MAP3K2
Sequence	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Subcellular Location	Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Yao Z, et al. Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. PLoS One, 2010 Sep 7.<br /><br />2. Cazares LH, et al. Maging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. Clin Cancer Res, 2009 Sep 1.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006842-1	PA1499	-	100 ug	$370		Add to Cart
BHA21006842-2	PA1499-10ug	Sample	10 ug	$99		Add to Cart
BHA21006842-3	PA1499-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006842-4	PA1499-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006842-5	PA1499-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006842-6	PA1499-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006842-7	PA1499-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006842-8	PA1499-FITC	FITC	100 ug	$570		Add to Cart
BHA21006842-9	PA1499-HRP	HRP	100 ug	$570		Add to Cart
BHA21006842-10	PA1499-APC	APC	100 ug	$670		Add to Cart
BHA21006842-11	PA1499-PE	PE	100 ug	$670		Add to Cart
BHA21006842-12	PA1499-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006842-13	PA1499-carrier-free	carrier-free	100 ug	$370		Add to Cart

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