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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MEK6/MAP2K6 Antibody Picoband®

SKU : BHA21007163

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Mfr.No.	PA1921, PA1921-10ug, PA1921-Biotin, PA1921-Cy3, PA1921-Dylight488, PA1921-Dylight550, PA1921-Dylight594, PA1921-FITC, PA1921-HRP, PA1921-APC, PA1921-PE, PA1921-iFluor647, PA1921-carrier-free
Alternative Names	Dual specificity mitogen-activated protein kinase kinase 6
Background	MAP2K6 (Mitogen-activated protein kinase kinase 6), also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene. It is located on chromosome 17. MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediatedsignal transduction pathway, this gene is involved in many cellular processes such as stress-induced cell cycle arrest, transcription activation and apoptosis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MEK6/MAP2K6 Antibody catalog # PA1921. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MA
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human MEK6, identical to the related mouse sequence and different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	22-24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dual specificity mitogen-activated protein kinase kinase 6;MAP kinase kinase 6;MAPKK 6;2.7.12.2;MAPK/ERK kinase 6;MEK 6;Stress-activated protein kinase kinase 3;SAPK kinase 3;SAPKK-3;SAPKK3;MAP2K6;MEK6, MKK6, PRKMK6, SKK3;
Tissue Specificity	Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P52564
Gene Name	MAP2K6
Sequence	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Subcellular Location	Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Binds to microtubules.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Han, J., Lee, J.-D., Jiang, Y., Li, Z., Feng, L., Ulevitch, R. J. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271: 2886-2891, 1996.<br /><br />2. Mao, Z., Bonni, A., Xia, F., Nadal-Vicans, M., Greenberg, M. E. Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 286: 785-790, 1999.<br /><br />3. Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J., Orth, K. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312: 1211-1214, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007163-1	PA1921	-	100 ug	$370		Add to Cart
BHA21007163-2	PA1921-10ug	Sample	10 ug	$99		Add to Cart
BHA21007163-3	PA1921-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007163-4	PA1921-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007163-5	PA1921-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007163-6	PA1921-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007163-7	PA1921-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007163-8	PA1921-FITC	FITC	100 ug	$570		Add to Cart
BHA21007163-9	PA1921-HRP	HRP	100 ug	$570		Add to Cart
BHA21007163-10	PA1921-APC	APC	100 ug	$670		Add to Cart
BHA21007163-11	PA1921-PE	PE	100 ug	$670		Add to Cart
BHA21007163-12	PA1921-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007163-13	PA1921-carrier-free	carrier-free	100 ug	$370		Add to Cart

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