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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MEK1/MAP2K1 Antibody Picoband®

SKU : BHA21003961

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Mfr.No.	A00292, A00292-10ug, A00292-Biotin, A00292-Cy3, A00292-Dylight488, A00292-Dylight550, A00292-Dylight594, A00292-FITC, A00292-HRP, A00292-APC, A00292-PE, A00292-iFluor647, A00292-carrier-free
Alternative Names	inducible T cell co-stimulator
Background	Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein(MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases(ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Rampoldi et al.(1997) localized the MAP2K1 gene to 15q22.1-q22.33.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MEK1/MAP2K1 Antibody Picoband® catalog # A00292. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient in
Host	Rabbit
Immunogen Region	E.coli-derived human MEK1/MAP2K1 recombinant protein (Position: M1-V393).
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; ICOS; AILIM
Tissue Specificity	Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newbo thymus.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q02750
Gene Id	5604
Gene Name	MAP2K1
Subcellular Location	Isoform 1: Cell membrane ; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Rat Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet 78 (3-4): 3013. 2. Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 114359.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003961-1	A00292	-	100 ug	$370		Add to Cart
BHA21003961-2	A00292-10ug	Sample	10 ug	$99		Add to Cart
BHA21003961-3	A00292-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003961-4	A00292-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003961-5	A00292-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003961-6	A00292-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003961-7	A00292-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003961-8	A00292-FITC	FITC	100 ug	$570		Add to Cart
BHA21003961-9	A00292-HRP	HRP	100 ug	$570		Add to Cart
BHA21003961-10	A00292-APC	APC	100 ug	$670		Add to Cart
BHA21003961-11	A00292-PE	PE	100 ug	$670		Add to Cart
BHA21003961-12	A00292-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003961-13	A00292-carrier-free	carrier-free	100 ug	$370		Add to Cart

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